 | | Vol. 17.40 – 11 October, 2023 |
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| The authors demonstrated that the immune checkpoint T cell immunoglobulin mucin-3 (TIM-3) was highly expressed in both tumor cells and microenvironmental cells, mainly microglia and macrophages, in diffuse intrinsic pontine glioma.
[Cancer Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that 32 individually addressable platinum microelectrodes integrated into laminin-coated branched polymer scaffolds stereotaxically injected to span a hydrogel-filled cortical lesion and deeper regions in the brains of mice promoted neural regeneration.
[Nature Biomedical Engineering] |
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| Investigators examined the impact of morphological perturbations on cell fate through integrated single nuclear RNA sequencing and spatial transcriptomics.
[Cell Stem Cell] |
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| Researchers demonstrated the efficacy of the PSAM4-GlyR was a modular system channel in silencing both mouse and human sensory neurons by the activation of large shunting conductances after agonist administration.
[Science Translational Medicine] |
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| The authors characterized the identity of cells arising from the subventricular zone after stroke and uncovered a mechanism through which they facilitated neural repair and functional recovery.
[Nature Communications] |
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| Scientists used patient-derived glioblastoma (GBM) stem cell cultures and combined single-cell RNA sequencing of GBM-associated macrophages (GAM)-GBM co-cultures and real-time in vivo monitoring of GAM-GBM interactions in orthotopic zebrafish xenograft models.
[EMBO Molecular Medicine] |
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| The authors reported that introduction of the codon-optimized wild-type human Presenilin (PSEN1) cDNA by adeno-associated virus 9 (AAV9) resulted in broadly distributed, sustained, low to moderate levels of human presenilin 1 expression.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators employed a 3D model of a human ductal epithelium to reveal tissue morphogenic defects result from loss of Notch1, but not Notch1 transcriptional signaling.
[Journal of Cell Biology] |
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| The authors explored hsa_circ_0054220 functions in Parkinson’s disease (PD). MPP-stimulated SH-SY5Y cells were established as the PD cell model.
[Applied Biochemistry and Biotechnology] |
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| White matter tracts (WMs) are one of the main invasion paths of glioblastoma multiforme (GBM). The lack of ideal research models hinders the understanding of the details and mechanisms of GBM invasion along WMs.
[Trends in Biotechnology] |
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| The Annemarie Opprecht-Foundation has announced MRC Laboratory of Molecular Biology group leaders Michel Goedert and Sjors Scheres as recipients of one of its 2023 Parkinson Awards.
[MRC Laboratory of Molecular Biology] |
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| Dr. Prabhu Arumugam has earned nearly $1.8 million from the US National Institute of Neurological Disorders and Stroke/National Institutes of Health (NIH) Small Business Technology Transfer program to continue his innovative development of implantable biosensor neural probes.
[Louisiana Tech University] |
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| October 22 – 25, 2023
Salt Lake City, Utah, United States |
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| | University of San Francisco – San Francisco, California, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Massachusetts General Hospital – Boston, Massachusetts, United States |
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| | Helmholtz Association of German Research Centres – Berlin, Germany |
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