 | | Vol. 17.41 – 18 October, 2023 |
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| Investigators showed that there was selective loss of synaptic connections between the cortex and striatum in postmortem tissue from patients with Huntington’s disease that is associated with the increased activation and localization of complement proteins, innate immune molecules, to these synaptic elements.
[Nature Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported the results of a first-in-human phase I trial in 41 patients with recurrent glioblastoma who were injected with CAN-3110—an oncolytic herpes virus.
[Nature] |
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| Researchers introduced a different method to acquire snapshots of single-cell cortical activity maps from freely-moving mice using a calcium sensor called CaMPARI.
[Nature Communications] |
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| The authors showed that high-mobility group AT-hook (HMGA) 2 mediated direct condensation of polynucleosomes and formed droplets with nucleosomes.
[Nature Communications] |
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| Scientists showed that TCF7L2, which was a key transcriptional effector of the Wnt/β-catenin pathway, played a cell-autonomous role in postnatal astrocyte maturation and impacted adult social behavior.
[Molecular Psychiatry] |
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| The authors reported that rat ventral tegmental area (VTA) dopamine neurons predominantly expressed hyperpolarization-activated cyclic nucleotide-gated (Hcn) 3-4 mRNA, while VTA GABA neurons expressed Hcn1–4 mRNA.
[Molecular Psychiatry] |
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| Investigators generated human brain organoids from induced pluripotent stem cells of healthy subjects and creatine transporter deficiency (CTD) patients. Brain organoids from CTD donors had reduced creatine uptake compared with those from healthy donors.
[eLife] |
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| Longitudinal RNA sequencing analyses identified the continuous induction of many RNA splicing regulators. Among these, the knockdown of RBFOX3, significantly abrogated the transdifferentiation.
[Stem Cell Reports] |
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| Hypoxic–ischemic brain damage (HIBD) was induced in postnatal day seven rats using the Rice-Vannucci method, and dexmedetomidine was administered intraperitoneally immediately after the HIBD induction.
[CNS Neuroscience & Therapeutics] |
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| Using ex vivo and in utero approaches in mouse embryos of both sexes, the authors found that Notch inhibition reduced the number of oligodendrocyte lineage cells in the dorsal pallium.
[Journal Of Neuroscience] |
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Numerous experimental models have been developed for glioblastoma, ranging from simple 2D cell cultures to study the nature of glioblastoma to complex 3D models as perfect prototypes to evaluate the therapeutic potential of different drugs.
[Heliyon] |
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| Researchers have created the largest atlas of human brain cells so far, revealing more than 3,000 cell types — many of which are new to science.
[Nature] |
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| Dr. Ilana Witten, a professor in the Princeton Neuroscience Institute, has been selected to receive a Director’s Pioneer Award from the National Institutes of Health (NIH).
[Princeton University] |
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| November 15 – 17, 2023
Seoul, Korea |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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| | University of San Francisco – San Francisco, California, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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