 | | Vol. 17.42 – 25 October, 2023 |
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| Using a central nervous system small-molecule inhibitor library of 320 agents known to be blood-brain barrier permeable and approved by the US FDA, breast cancer brain metastases vulnerabilities were interrogated to identify an effective agent.
[Journal Of Clinical Investigation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators determined the projection patterns of more than 3,000 macaque basolateral amygdala (BLA) neurons. They found that one-third of BLA neurons had two or more distinct projection targets in frontal cortex and subcortical structures.
[Neuron] |
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| The authors discovered that isocitrate dehydrogenase type 1 (IDH1) mutation inhibited virus-induced interferon antiviral responses in glioma cells.
[Nature Communications] |
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| Scientists showed in mice that ApoE4 and follicle–stimulating hormone (FSH) jointly triggered Alzheimer’s disease-like pathogenesis by activating C/EBPβ/δ-secretase signaling.
[Nature Communications] |
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| Investigators examined the effect of human cerebrospinal fluid (CSF) on glioblastoma (GBM) tumors from 25 patients. They found that CSF induced tumor cell plasticity and resistance to standard GBM treatments, temozolomide and irradiation.
[Science Advances] |
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| The authors examined the effects of repeated post-kainate (KA) treatment with ramelteon, a selective agonist of melatonin receptors, on neuronal loss, cognitive impairment, and depression-like behaviors following KA-induced seizures.
[Journal of Pineal Research] |
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| Scientists reported in a tauopathy mouse model that apolipoprotein E4 (APOE4) promoted the nucleocytoplasmic translocation and release of high-mobility group box 1 (HMGB1) from hippocampal neurons, which correlated with the severity of hippocampal microgliosis and degeneration.
[Cell Reports] |
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| The timeline of astrocyte development and maturation in cerebral organoids is currently unknown and this limits the value and applicability of the model. Therefore, researchers generated cerebral organoids from three healthy individuals and assessed astrocyte maturation after 5, 11, 19, and 37 weeks in culture.
[Glia] |
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| Immunocompetent adult female rats received either controlled cortical impact injury or sham surgery. LMNSC008 cells or a vehicle were administered intranasal on postoperative days 7, 9, 11, 13, 15, and 17.
[Scientific Reports] |
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| Not only do neuron–oligodendroglial interactions modulate neural circuit structure and function in the healthy brain, but neuron–glioma interactions also have important roles in the pathogenesis of glial malignancies.
[Nature Reviews Neuroscience] |
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| The authors propose an intuitive, data-driven, and transferable conceptual framework called ‘contextual guidance’. It describes astrocytes as ‘contextual gates’ that shape neural circuitry in an adaptive, state-dependent fashion.
[Nature Neuroscience] |
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| A $3.6 million award from the National Institutes of Health will allow neurosurgical, neurology and neuroscience researchers at The Ohio State University Wexner Medical Center and College of Medicine to test a novel diagnosis and treatment combination for painful diabetic neuropathy.
[The Ohio State University] |
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| Benjamin Ryskeldi-Falcon, Group Leader in the LMB’s Neurobiology Division, has been announced as the 2023 winner of the SCOR Young European Researcher Prize, awarded by the Alzheimer Research Foundation and the SCOR Foundation for Science.
[MRC Laboratory of Molecular Biology] |
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| November 26 – 29, 2023
Buxted Park, England, United Kingdom |
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| | Westlake University – Zhejiang, China |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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| | Massachusetts General Hospital – Boston, Massachusetts, United States |
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| | University of Michigan-Ann Arbor – Ann Arbor, Michigan, United States |
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