 | | Vol. 17.43 – 1 November, 2023 |
| |
|
|
| Scientists generated microglia-sufficient brain organoids by coculturing brain organoids with primitive-like macrophages generated from the same human induced pluripotent stem cells.
[Nature] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The authors identified a previously unreported neurotoxic microglial state demarcated by elevated expression of CHIT1 specific to the aged spinal cords in non-human primate and human biopsies.
[Nature] |
|
|
|
| The engineering of hippocampus neuron cell-derived exosomes to overexpress Fe65, enabled the development of a novel exosome-based targeted drug delivery system, which carried Corynoxine-B to the amyloid-β precursor protein overexpressed-neuron cells in the brain of Alzheimer’s disease mice.
[Signal Transduction and Targeted Therapy] |
|
|
|
| Investigators showed that Tau arrested liquid-like droplets formed by the four postsynaptic density proteins PSD-95, GKAP, Shank, Homer in solution, as well as N-methyl-D-aspartate-receptor-associated protein clusters on synthetic membranes.
[Nature Communications] |
|
|
|
| Using autoradiography and radiobinding techniques, researchers showed that the positron emission tomography (PET) ligand, ACI-12589, displayed good in vitro affinity and specificity for pathological α-synuclein in tissues from patients with different α-synuclein-related disorders.
[Nature Communications] |
|
|
|
| Investigators examined the effect of human cerebrospinal fluid (CSF) on glioblastoma (GBM) tumors from 25 patients. They found that CSF induces tumor cell plasticity and resistance to standard GBM treatments, temozolomide and irradiation.
[Science Advances] |
|
|
|
| Researchers identified SorCS2 as a progranulin receptor that was required for motor neuron diversification and axon outgrowth in zebrafish and mice.
[Cell Reports] |
|
|
|
| Investigators identified the tripartite motif-containing protein, TRIM26 as an E3 ubiquitin ligase of GPX4. TRIM26 directly interacted with GPX4 through its Ring domain and catalyzed the ubiquitination of GPX4 at K107 and K117.
[Cell Death & Disease] |
|
|
|
| Scientists tested the potential activity and the underlying mechanisms of neuroligin-3 (NLGN3) against ischemia-reperfusion-induced neuronal cell injury.
[Cell Death & Disease] |
|
|
|
| The authors showed that Parkinson’s disease-linked missense mutations in SNCA impacted activity-dependent pS129. Under basal conditions, cytosol-enriched A30P, H50Q, and G51D mutant forms of α-synuclein exhibited reduced pS129 levels in rat primary cortical neurons.
[EMBO Reports] |
|
|
|
| To study whether the TSPO ligand XBD173 may exert early neuroprotective effects in Alzheimer’s disease (AD) pathology, researchers investigated the impact of XBD173 on amyloid toxicity and neuroplasticity in mouse models of AD.
[Translational Psychiatry] |
|  |
|
|
|
| The authors emphasize the intricate role of receptor tyrosine kinase signaling pathways, epigenetic mechanisms, and metabolic functions in glioblastoma tumorigenesis and therapeutic resistance.
[Signal Transduction and Targeted Therapy] |
|
|
|
| Scientists discuss the role of astrocytic mitochondria in the pathogenesis of brain ischemic injury and their potential as a therapeutic target.
[Molecular Neurobiology] |
|
|
|
|
| Two junior faculty in the Department of Neuroscience at Yale School of Medicine. Emilia Favuzzi, PhD, assistant professor, and Tristan Geiller, PhD, incoming assistant professor in January 2024, are being honored with the 2023 Peter and Patricia Gruber International Research Award in Neuroscience.
[Yale School of Medicine] |
|
|
|
|
| November 7 – 8, 2023
London, England, United Kingdom |
|
|
|
|
|
| | Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| | Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| | Cedars-Sinai – Los Angeles, California, United States |
|
|
|
| | King’s College London – London, England, United Kingdom |
|
|
|
| | Westlake University – Zhejiang, China |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
