 | | Vol. 17.44 – 8 November, 2023 |
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| Investigators developed a neuroprosthesis operating in closed loop that targeted the dorsal root entry zones innervating lumbosacral segments to reproduce the natural spatiotemporal activation of the lumbosacral spinal cord during walking.
[Nature Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors revealed that the adenosine in CAG repeat RNA could be methylated to N1-methyladenosine (m1A) by TRMT61A, and that m1A could be demethylated by ALKBH3.
[Nature] |
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| Scientists indicated that brain-derived neurotrophic factor–tropomyosin-related kinase B signaling promoted malignant synaptic plasticity and augmented tumor progression.
[Nature] |
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| Researchers found that suppressing the firing of cerebellar Purkinje cells rapidly excited forebrain areas that contributed to functions such as emotional regulation and motor functions but that the classic cerebellar outputs, the deep cerebellar nuclei, did not directly project there.
[Nature Neuroscience] |
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| Investigators uncovered in Drosophila melanogaster a glia-to-neuron alanine transfer involving alanine aminotransferase that sustained memory formation.
[Nature Metabolism] |
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| The authors described an integrated neurodegeneration checkpoint response to early pathological changes that restricted further disease progression and preserves cognitive function.
[Nature Communications] |
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| Researchers developed an mEos-based aSyn seeding assay and performed saturation mutagenesis to identify with single-residue resolution positive and negative regulators of aSyn aggregation.
[Science Advances] |
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| Consistent with the accumulation of extracellular matrix (ECM) in the hippocampus observed with aging, the authors found that tissue inhibitor of metalloproteinases-2 (TIMP2) acted to reduce the accumulation of ECM around synapses in the hippocampus.
[Molecular Psychiatry] |
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| Scientists investigated the role of surround inhibition for the intrinsic function of the striatum. Large-scale striatal networks of 20 to 40 thousand neurons were simulated with detailed multicompartmental models of different cell types, corresponding to the size of a module of the dorsolateral striatum.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators demonstrated that treatment with recombinant high mobility group box 1 (HMGB1) stimulated astrocytes to induce hepcidin expression in a toll-like receptor 4- and CXCR4-dependent manner.
[Experimental & Molecular Medicine] |
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| The authors review evidence collected by magnetic resonance imaging techniques that indicate white matter (WM) abnormalities in Parkinson’s disease (PD) and discuss the correlations between WM changes and specific PD symptoms.
[npj Parkinson’s Disease] |
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| USC Stem Cell scientist Justin Ichida has learned to inhabit two worlds: the university where his lab makes discoveries, and the companies that can help commercialize these discoveries into new treatments for neurodegenerative diseases.
[Keck School of Medicine of USC] |
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| Gregory Petsko, Harvard Medical School professor of neurology at Brigham and Women’s Hospital, has been awarded a 2022 National Medal of Science.
[Harvard Medical School] |
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| November 28 – 30, 2023
San Francisco, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Tufts University School of Medicine – Boston, Massachusetts, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | King’s College London – London, England, United Kingdom |
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