Neural Cell News Volume 17.45 | Nov 15 2023

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    2023-11-15 | NCN 17.45


    Neural Cell News by STEMCELL Technologies
    Vol. 17.45 – 15 November, 2023
    TOP STORY

    The Circadian Clock Time Tunes Axonal Regeneration

    A comparative analysis of transcriptomic datasets associated with neuronal regenerative ability revealed circadian rhythms as the most significantly enriched pathway.
    [Cell Metabolism]

    AbstractGraphical Abstract
    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    PUBLICATIONSRanked by the impact factor of the journal

    Non-Synaptic Function of the Autism Spectrum Disorder-Associated Gene SYNGAP1 in Cortical Neurogenesis

    In a human cortical organoid model of SYNGAP1 haploinsufficiency, researchers found dysregulated cytoskeletal dynamics that impaired the scaffolding and division plane of human radial glia cells.
    [Nature Neuroscience]

    AbstractPress Release

    Chemogenetic Approaches Reveal Dual Functions of Microglia in Seizures

    The authors employed chemogenetic manipulation of microglia using the artificial Gi-Dreadd receptor within a kainic acid induced murine seizure model.
    [Brain Behavior And Immunity]

    AbstractGraphical Abstract

    Knockout or Inhibition of USP30 Protects Dopaminergic Neurons in a Parkinson’s Disease Mouse Model

    Investigators showed that loss of USP30 in Usp30 knockout mice protected against behavioral deficits and led to increased mitophagy, decreased phospho-S129 α-synuclein (αSyn), and attenuation of SN dopaminergic neuronal loss induced by αSyn.
    [Nature Communications]

    Full Article

    Tau Forms Synaptic Nano-Biomolecular Condensates Controlling the Dynamic Clustering of Recycling Synaptic Vesicles

    The authors performed a large-scale activity-dependent phosphoproteome analysis of hippocampal neurons in vitro and identified Tau as a highly phosphorylated and disordered candidate protein.
    [Nature Communications]

    Full Article

    ARL6IP1 Gene Delivery Reduces Neuroinflammation and Neurodegenerative Pathology in Hereditary Spastic Paraplegia Model

    Investigators clarified the molecular mechanism of ARL6IP1 in hereditary spastic paraplegia using in vitro and in vivo models.
    [Journal of Experimental Medicine]

    Full Article
    Graphical
    Abstract

    Impaired Neural Stress Resistance and Loss of REST in Bipolar Disorder

    Researchers described a human cerebral organoid model of bipolar disorder that exhibited altered neural development, elevated neural network activity, and a major shift in the transcriptome.
    [Molecular Psychiatry]

    Abstract

    Temporally Specific Gene Expression and Chromatin Remodeling Programs Regulate a Conserved Pdyn Enhancer

    Scientists used transcriptomic and chromatin accessibility profiling to define activity-driven responses in rat striatal neurons.
    [eLife]

    Full Article

    The Aminosteroid U73122 Promotes Oligodendrocytes Generation and Myelin Formation

    Investigators discovered that U73122, a phosphoinositide-specific phospholipase C inhibitor, dramatically promoted oligodendrocyte precursor cell-to-oligodendrocyte differentiation and myelin regeneration in the experimental autoimmune encephalomyelitis model.
    [Acta Pharmacologica Sinica]

    Abstract
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    REVIEWS

    Mechanism and Therapeutic Potential of Targeting cGAS-STING Signaling in Neurological Disorders

    Scientists cover the current understanding of the molecular mechanisms of cyclic GMP-AMP synthase (cGAS) activation and highlight cGAS-stimulator of interferon genes (STING) signaling in various cell types of central and peripheral nervous systems, such as resident brain immune cells, neurons, and glial cells.
    [Molecular Neurodegeneration]

    Full Article

    Peptide-Based Approaches to Directly Target Alpha-Synuclein in Parkinson’s Disease

    The authors describe and summarize the current efforts made in the development of peptides and their mimetics to directly engage with alpha-synuclein with the intention of modulating aggregation, and importantly, toxicity.
    [Molecular Neurodegeneration]

    Full Article

    STING Signaling in the Brain: Molecular Threats, Signaling Activities, and Therapeutic Challenges

    Investigators summarize how molecular threats activate STING signaling in the diseased brain and how STING signaling activities in glial and neuronal cells cause neuropathology.
    [Neuron]

    Abstract
    INDUSTRY AND POLICY NEWS

    Three Investigators Named Winners of Memorial Sloan Kettering Cancer Center’s 2023 Paul Marks Prize for Cancer Research

    Memorial Sloan Kettering Cancer Center has announced three innovative investigators as the recipients of this year’s Paul Marks Prize for Cancer Research.
    [Memorial Sloan Kettering Cancer Center]

    Press Release

    The Paul G. Allen Frontiers Group Announces Allen Discovery Center for Neuroimmune Interactions at Icahn School of Medicine at Mount Sinai

    The Paul G. Allen Frontiers Group announced the launch of the Allen Discovery Center for Neuroimmune Interactions at the Icahn School of Medicine at Mount Sinai.
    [Allen Institute]

    Press Release
    FEATURED EVENT

    Cell Bio 2023

    December 2 – 6, 2023
    Boston, Massachusetts, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellowships – Cancer Research

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Postdoctoral Researcher – Cancer Bioinformatics and Immunotherapies

    Armenian Bioinformatics Institute – Yerevan, Armenia

    Research Associate – Systems Neuroscience

    Baylor College of Medicine – Houston, Texas, United States

    Assistant/Associate/Full Professor – Neuroscience

    Tufts University School of Medicine – Boston, Massachusetts, United States

    Postdoctoral Associate – Brain Tumor Research

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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