Neural Cell News Volume 17.46 | Nov 22 2023

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    Noshin Noorjahan
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    2023-11-22 | NCN 17.46


    Neural Cell News by STEMCELL Technologies
    Vol. 17.46 – 22 November, 2023
    TOP STORY

    A Tool Kit of Highly Selective and Sensitive Genetically Encoded Neuropeptide Sensors

    To permit the fast and scalable development of neuropeptide sensors, scientists developed an intracellular loop 3 grafting method that efficiently generated genetically encoded fluorescent sensors.
    [Science]

    AbstractGraphical Abstract
    Guide to everything you need to know about cell separation.
    PUBLICATIONSRanked by the impact factor of the journal

    FMRP Phosphorylation Modulates Neuronal Translation through YTHDF1

    Researchers reported a mechanism that the stimuli-induced neuronal translation was mediated by phosphorylation of a YTHDF1-binding protein FMRP.
    [Molecular Cell]

    AbstractGraphical Abstract

    Targeted Suppression of mTORC2 Reduces Seizures across Models of Epilepsy

    The authors discovered that genetic deletion of mTOR complex 2 (mTORC2) from forebrain neurons was protective against kainic acid-induced behavioral and electroencephalogram seizures.
    [Nature Communications]

    Full Article

    Altered Corollary Discharge Signaling in the Auditory Cortex of a Mouse Model of Schizophrenia Predisposition

    Investigators examined the processing of self-generated sounds in male Df(16)A+/− mice, which model one of the largest genetic risk factors for schizophrenia, the 22q11.2 microdeletion.
    [Nature Communications]

    Full Article

    MKL/SRF and Bcl6 Mutual Transcriptional Repression Safeguards the Fate and Positioning of Neocortical Progenitor Cells Mediated by RhoA

    Using in vivo functional approaches combined with molecular mechanistic analysis, scientists identified a reciprocal regulatory loop between B cell lymphoma 6 (Bcl6) and the RhoA-regulated transcriptional complex megakaryoblastic leukemia/serum response factor (MKL/SRF).
    [Science Advances]

    Full Article

    Leukotriene A4 Hydrolase Inhibition Improves Age-Related Cognitive Decline via Modulation of Synaptic Function

    Researchers identified that the enzyme leukotriene A4 hydrolase (LTA4H) was expressed in healthy mouse neurons, and inhibition of LTA4H in aged mice improved hippocampal dependent memory.
    [Science Advances]

    Full Article

    Mitigating Aberrant Cdk5 Activation Alleviates Mitochondrial Defects and Motor Neuron Disease Symptoms in Spinal Muscular Atrophy

    The authors reported that the activity of cyclin-dependent kinase 5 (Cdk5) and the conversion of its activating subunit p35 to the more potent activator p25 were significantly up-regulated in mouse models and human induced pluripotent stem cell models of spinal muscular atrophy.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Single-Cell Transcriptomics of Human Traumatic Brain Injury Reveals Activation of Endogenous Retroviruses in Oligodendroglia

    Researchers used single-nuclei RNA sequencing to study transcriptomic changes in different cell populations in human brain tissue obtained acutely after severe, life-threatening traumatic brain injury.
    [Cell Reports]

    Full ArticleGraphical Abstract

    O-GlcNAcylation of Melanophilin Enhances Radiation Resistance in Glioblastoma via Suppressing TRIM21 Mediated Ubiquitination

    Investigators found that melanophilin was significantly upregulated in recurrent glioblastoma tumor tissues after ionizing radiation.
    [Oncogene]

    Abstract
    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    REVIEWS

    Molecular Biomarkers for Vascular Cognitive Impairment and Dementia

    Scientists examine the roles of large and small vessel disease in vascular cognitive impairment and dementia, considering the underlying pathophysiological processes that lead to vascular brain injury.
    [Nature Reviews Neurology]

    Abstract

    Neuroinflammation: An Astrocyte Perspective

    The authors highlight the intricate interactions between astrocytes, other central nervous system (CNS)-resident cells, and CNS-infiltrating cells as well as their potential therapeutic value in the context of inflammation and neurodegeneration.
    [Science Translational Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Only 0.5% of Neuroscience Studies Look at Women’s Health. Here’s How to Change That

    More than 50,000 human-brain-imaging articles have been published since MRI came on the scene in the 1990s. But of those, less than 0.5% consider health factors specific to women.
    [Nature]

    Editorial
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    JOB OPPORTUNITIES

    Postdoctoral Associate – Cancer Neuroscience

    Baylor College of Medicine – Houston, Texas, United States

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    Babraham Institute – Cambridge, England, United Kingdom

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    University of Oxford – Oxford, England, United Kingdom

    Postdoctoral Fellowships – Cancer Research

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Postdoctoral Researcher – Cancer Bioinformatics and Immunotherapies

    Armenian Bioinformatics Institute – Yerevan, Armenia

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