 | | Vol. 17.47 – 29 November, 2023 |
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| Researchers showed that multiple regionally distinct neural stem cells, including domains that are usually quiescent, are recruited on different gestation days during pregnancy.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that stathmin-2 had an important role in the establishment and maintenance of neurofilament-dependent axoplasmic organization that is critical for preserving the caliber and conduction velocity of myelinated large-diameter axons.
[Nature Neuroscience] |
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| Scientists investigated the impact of nanoparticle surface chemistry using layer-by-layer assembly to design drug carriers for broad spatial distribution in brain tissue and specific glioblastoma cell targeting.
[ACS Nano] |
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| Using single-nucleus RNA sequencing, investigators showed that the autism spectrum disorder gene, lysine demethylase 5A (KDM5A), regulated the development of specific subtypes of excitatory and inhibitory neurons.
[Science Advances] |
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| Investigators showed that NSD1, the methyltransferase for di-methylated lysine 36 of histone H3, controlled both area and layer identities of the neocortex.
[Cell Reports] |
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| Researchers introduced third-generation rabies viral vectors, which appearred to be as nontoxic as second-generation ones but have the major advantage of growing to much higher titers, resulting in significantly increased numbers of retrogradely labeled neurons in vivo.
[Cell Reports Methods] |
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| Investigators developed a human brain organoid technique that generated self-organizing, single-rosette cortical organoids with reproducible size and structure at early timepoints.
[Stem Cell Reports] |
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| Retrovirus-mediated expression of Neurog2 induced the glutamatergic lineage markers TBR2 and TBR1 in cultured subependymal zone progenitors, which differentiated into functional glutamatergic neurons.
[Stem Cell Reports] |
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| Investigators created a comprehensive atlas of small ncRNA species during iPSC-derived sensory neuron differentiation. Utilizing iPSC-derived sensory neurons and human dorsal root ganglia RNA sequencing, they unveiled signatures describing developmental processes.
[iScience] |
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| Scientists treated 3D neuro-spheroids with fasudil and tested the possible effect on Alzheimer’s disease markers by ELISA, transcriptomic and proteomic analyses.
[Journal Of Alzheimers Disease] |
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| The authors applied CRISPR gene editing and iPSC neural disease modeling to assess the variant. During differentiation from iPSCs to neural progenitors, they detected subtle, but significant gene signatures in synaptic transmission and muscle contraction pathways.
[HGG Advances] |
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| Scientists consider what the field has learned from studies of ketamine and to suggest future directions for the optimization of rapid-acting antidepressant treatment.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| bit.bio, the company coding human cells for novel cures, and the Institute of Psychiatry, Psychology & Neuroscience at King’s College London today announce a collaboration to build multi-cell models of the human brain using bit.bio’s ioCells™️.
[bit.bio (BusinessWire, Inc.)] |
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| January 17 – 19, 2024
Chiba, Japan |
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| | BC Cancer – Vancouver, British Columbia, Canada |
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| | University of Exeter – Exeter, England, United Kingdom |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Babraham Institute – Cambridge, England, United Kingdom |
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| | University of Oxford – Oxford, England, United Kingdom |
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