 | | Vol. 17.48 – 6 December, 2023 |
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| The authors generated single-nucleus RNA-sequencing data for ~400,000 cells to trace cerebellum development from early neurogenesis to adulthood in human, mouse, and the marsupial opossum.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that initiating neural induction in a temporal stepwise gradient guided the generation of brain organoids composed of a single, self-organized apical-out neuroepithelium.
[Nature Communications] |
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| Scientists found increased expression of the C16:0 ceramide-producing ceramide synthase (CerS)6 in cultured hypothalamic neurons exposed to palmitate in vitro and in the hypothalamus of obese mice.
[Nature Communications] |
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| Investigators showed that the PTENG132D allele disrupted early neuroectoderm formation during the first several days of organoid generation, and results in deficient electrophysiology.
[Molecular Psychiatry] |
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| The authors found that HECW1 decreased the survival rate of glioma cells and enhanced iron accumulation, lipid peroxidation, whereas ZNF350 showed the opposite effect.
[Cell Death & Disease] |
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| Researchers developed a novel technique for creating self-assembled nanoparticles utilizing a range of natural bioactive molecules. These nanoparticles could encapsulate insoluble drugs and effectively cross the blood–brain barrier.
[CNS Neuroscience & Therapeutics] |
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| The authors reported using human tumor specimens and primary spheroids from male and female patients that GlialCAM, was differentially expressed in subpopulations of glioblastoma cells.
[Journal Of Neuroscience] |
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| Using multicolor two-photon microscopy, scientists tested how amyloid pathology altered the structural dynamics of excitatory and inhibitory synapses and their adaptation to altered visual experience in vivo in the visual cortex.
[Journal Of Neuroscience] |
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| Researchers described a method for generating functional neural spheroids by cell-aggregation of differentiated human iPSC-derived neurons and astrocytes at cell type compositions mimicking specific regions of the human brain.
[Communications Biology] |
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| Investigators studied the coassembly of the ganglioside GM1 and the amyloid β (Aβ) peptides Aβ40 and 42 by means of microfluidic diffusional sizing, confocal microscopy, and cryogenic transmission electron microscopy.
[ACS Chemical Neuroscience] |
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| The authors explored the possibility of inducing aging-associated features in cell types of the central nervous system using hiPSC technology.
[Biogerontology] |
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| Investigators discuss recent advances in understanding the molecular and cellular pathways that impair synapses in neurodegenerative diseases, including the effects of protein aggregation and neuroinflammation.
[Nature Reviews Drug Discovery] |
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| The NIH has paused the start of a major human trial of an experimental drug aimed at protecting the brain after a stroke and launched an investigation into recently aired concerns about the drug’s safety and whether lab studies supporting its promise contain manipulated images and data.
[Science] |
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| January 16 – 19, 2024
San Diego, California, United States & Virtual |
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| | The Hong Kong University of Science and Technology – Guangzhou, China |
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| | University of Texas Health Science Center at San Antonio – San Antonio, Texas, United States |
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| | Jinfeng Labs & Institute of Functional Genomics – Chongqing, China |
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| | Institut Necker Enfants Malades – Paris, France |
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| | Zhejiang Chinese Medical University – Hangzhou, China |
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