Neural Cell News Volume 17.49 | Dec 13 2023

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    2023-12-13 | NCN 17.49


    Neural Cell News by STEMCELL Technologies
    Vol. 17.49 – 13 December, 2023
    TOP STORY

    TAF15 Amyloid Filaments in Frontotemporal Lobar Degeneration

    Scientists used cryogenic electron microscopy to determine the structures of amyloid filaments extracted from the prefrontal and temporal cortices of four individuals with frontotemporal lobar degeneration–fused in sarcoma.
    [Nature]

    Full Article
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    INPP5D Regulates Inflammasome Activation in Human Microglia

    Through unbiased analyses of RNA and protein profiles in INPP5D-disrupted iPSC-derived human microglia, the authors found that reduction in INPP5D activity was associated with molecular profiles consistent with disrupted autophagy and inflammasome activation.
    [Nature Communications]

    Full Article

    Isochronic Development of Cortical Synapses in Primates and Mice

    Researchers found that excitatory and inhibitory synapses in the male Mus musculus and Rhesus macaque cortex formed at similar rates, at similar times after birth.
    [Nature Communications]

    Full Article

    Econazole Selectively Induces Cell Death in NF1-Homozygous Mutant Tumor Cells

    Investigators screened a library of FDA-approved drugs using a cutaneous neurofibromas cell model derived from human induced pluripotent stem cells generated from an NF1 patient.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Human-Specific Features and Developmental Dynamics of the Brain N-glycome

    The authors performed multiregional characterization of rat, macaque, chimpanzee, and human brain N-glycomes using chromatography and mass spectrometry and then integrated these data with complementary glycotranscriptomic data.
    [Science Advances]

    Full Article

    Brain-Wide Circuit-Specific Targeting of Astrocytes

    Scientists showed that without exogenous expression of NS1 at the postsynaptic sites, locally injected YFVΔNS1-Cre selectively turned on reporter genes in astrocytes in downstream brain regions.
    [Cell Reports Methods]

    Full ArticleGraphical Abstract

    HB-EGF Promotes Progenitor Cell Proliferation and Sensory Neuron Regeneration in the Zebrafish Olfactory Epithelium

    Researchers showed that expression of the heparin-binding epidermal growth factor-like growth factor (HB-EGF) was strongly and transiently upregulated in response to olfactory epithelium injury and signaled through the EGF receptor, which was expressed by horizontal basal cells.
    [FEBS Journal]

    Abstract

    Simvastatin Differentially Modulates Glial Functions in Cultured Cortical and Hypothalamic Astrocytes Derived from Interferon α/β Receptor Knockout Mice

    The authors investigated the effects of simvastatin in inflammatory and functional parameters of primary cortical and hypothalamic astrocyte cultures obtained from IFNα/β receptor knockout mice.
    [Neurochemical Research]

    Abstract

    Transplantation of Neural Stem Cells-Overexpressed Ku70 Improves Neurological Deficits in a Mice Model of Cerebral Ischemia Stroke

    NSCs were induced by oxygen-glucose deprivation/reoxygenation for constructing cerebral ischemic stroke cell model.
    [Neurochemical Research]

    Abstract
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    REVIEWS

    White Matter Injury across Neurodegenerative Disease

    The authors focus primarily on three degenerative disorders in which white matter loss is well documented: Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. They discuss clinical data implicating white matter injury as a key feature of these disorders.
    [Trends In Neurosciences]

    Abstract
    INDUSTRY AND POLICY NEWS

    Surge in Number of ‘Extremely Productive’ Authors Concerns Scientists

    Some researchers publish a new paper every five days, on average. Data trackers suspect not all their manuscripts were produced through honest labor.
    [Nature]

    Editorial
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    JOB OPPORTUNITIES

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    Jinfeng Labs & Institute of Functional Genomics – Chongqing, China

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