| Vol. 17.49 – 13 December, 2023 |
| |
|
|
| Scientists used cryogenic electron microscopy to determine the structures of amyloid filaments extracted from the prefrontal and temporal cortices of four individuals with frontotemporal lobar degeneration–fused in sarcoma. [Nature] |
|
|
|
|
PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Through unbiased analyses of RNA and protein profiles in INPP5D-disrupted iPSC-derived human microglia, the authors found that reduction in INPP5D activity was associated with molecular profiles consistent with disrupted autophagy and inflammasome activation. [Nature Communications] |
|
|
|
| Researchers found that excitatory and inhibitory synapses in the male Mus musculus and Rhesus macaque cortex formed at similar rates, at similar times after birth. [Nature Communications] |
|
|
|
| Investigators screened a library of FDA-approved drugs using a cutaneous neurofibromas cell model derived from human induced pluripotent stem cells generated from an NF1 patient. [Cell Reports Medicine] |
|
|
|
| The authors performed multiregional characterization of rat, macaque, chimpanzee, and human brain N-glycomes using chromatography and mass spectrometry and then integrated these data with complementary glycotranscriptomic data. [Science Advances] |
|
|
|
| Scientists showed that without exogenous expression of NS1 at the postsynaptic sites, locally injected YFVΔNS1-Cre selectively turned on reporter genes in astrocytes in downstream brain regions. [Cell Reports Methods] |
|
|
|
| Researchers showed that expression of the heparin-binding epidermal growth factor-like growth factor (HB-EGF) was strongly and transiently upregulated in response to olfactory epithelium injury and signaled through the EGF receptor, which was expressed by horizontal basal cells. [FEBS Journal] |
|
|
|
| The authors investigated the effects of simvastatin in inflammatory and functional parameters of primary cortical and hypothalamic astrocyte cultures obtained from IFNα/β receptor knockout mice. [Neurochemical Research] |
|
|
|
| NSCs were induced by oxygen-glucose deprivation/reoxygenation for constructing cerebral ischemic stroke cell model. [Neurochemical Research] |
|
|
|
|
| The authors focus primarily on three degenerative disorders in which white matter loss is well documented: Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. They discuss clinical data implicating white matter injury as a key feature of these disorders. [Trends In Neurosciences] |
|
|
|
|
| Some researchers publish a new paper every five days, on average. Data trackers suspect not all their manuscripts were produced through honest labor. [Nature] |
|
|
|
|
| February 8 – 11, 2024 Cancun, Mexico |
|
|
|
|
|
| University of Michigan – Ann Arbor, Michigan, United States |
|
|
|
| University of Surrey – Surrey, England, United Kingdom |
|
|
|
| The Hong Kong University of Science and Technology – Guangzhou, China |
|
|
|
| University of Texas Health Science Center at San Antonio – San Antonio, Texas, United States |
|
|
|
| Jinfeng Labs & Institute of Functional Genomics – Chongqing, China |
|
|
|
|