Neural Cell News Volume 18.01 | Jan 17 2023

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    Jamie Kang
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    2024-01-17 | NCN 18.02


    Neural Cell News by STEMCELL Technologies
    Vol. 18.01 – 17 January, 2024
    TOP STORY

    Repeated Peripheral Infusions of Anti-EGFRvIII CAR T Cells in Combination with Pembrolizumab Show No Efficacy in Glioblastoma: A Phase I Trial

    Researchers conducted a Phase I trial of CAR T-EGFRvIII cells administered concomitantly with the anti-PD1 monoclonal antibody pembrolizumab in patients with newly diagnosed, EGFRvIII+ glioblastoma.
    [Nature Cancer]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    TREM2 Variants that Cause Early Dementia and Increase Alzheimer’s Disease Risk Affect Gene Splicing

    Investigators tested whether disease-associated TREM2 variants contribute to the pathology via altered splicing. Their findings revealed an unanticipated complexity of pathogenic variation in TREM2, in which effects on post-transcriptional gene regulation and protein function often coexist.
    [Brain]

    Abstract

    Molecular Profiling of Human Substantia Nigra Identifies Diverse Neuron Types Associated with Vulnerability in Parkinson’s Disease

    Scientists identified cell clusters representing various neuron types, glia, endothelial cells, pericytes, fibroblasts, and T cells and investigated cell type–dependent alterations in gene expression in Parkinson’s disease.
    [Science Advances]

    Full Article

    Dopamine Neuron Degeneration in the Ventral Tegmental Area Causes Hippocampal Hyperexcitability in Experimental Alzheimer’s Disease

    Investigators supported the hypothesis that the Ventral Tegmental Area dopaminergic system integrity plays a key role in hippocampal Parvalbumin interneurons function and survival, disclosing a relevant contribution of the reduced dopaminergic tone to aberrant gamma-waves, hippocampal hyperexcitability, and epileptiform activity in early Alzheimer’s disease.
    [Molecular Psychiatry]

    Full Article

    Neural Stem Cell Homeostasis Is Affected in Cortical Organoids Carrying a Mutation in Angiogenin

    Researchers obtained skin fibroblasts from members of amyotrophic lateral sclerosis and frontotemporal dementia family. They reprogrammed these fibroblasts to induced pluripotent stem cells (iPSCs) and generated cortical organoids as well as induced stage-wise differentiation of the iPSCs to neurons.
    [Journal Of Pathology]

    Full Article

    IFITM3 Promotes Glioblastoma Stem Cell-Mediated Angiogenesis via Regulating JAK/STAT3/bFGF Signaling Pathway

    The authors investigated the expression of interferon-induced transmembrane protein 3 (IFITM3) in glioma datasets culled from The Cancer Genome Atlas and Chinese Glioma Genome Atlas. Primary glioblastoma multiforme stem cells were cultured and identified in vitro.
    [Cell Death & Disease]

    Full Article

    Using Human Fetal Neural Stem Cells to Elucidate the Role of the JAK-STAT Cell Signaling Pathway in Oligodendrocyte Differentiation In Vitro

    Scientists investigated and elucidated the cell signaling pathways implicated in the developmental maturation of oligodendrocytes using human fetal neural stem cells –derived primary oligodendrocytes and MO3.13 cell line.
    [Molecular Neurobiology]

    Abstract

    Cationic Hydrogels Modulate Neural Stem and Progenitor Cell Proliferation and Differentiation Behavior in Dependence of Cationic Moiety Concentration in 2D Cell Culture

    Researchers developed a well-defined, fully synthetic hydrogel system that allowed for the precise control of the concentration of cationic trimethylaminoethyl acrylate molecules associated with the polymer. They observed a strong correlation between cationic charge concentration with NSPC survival.
    [ACS Biomaterials Science & Engineering]

    AbstractGraphical Abstract

    ALKBH5 Is a Prognostic Factor and Promotes the Angiogenesis of Glioblastoma

    Scientists investigated the relevance between RNA modification regulators and glioblastoma angiogenesis. They discovered that ALKBH5 knock-down of U87 cells could decrease the pro-angiogenesis ability of U87 GBM cells.
    [Scientific Reports]

    Full Article

    bHLH Transcription Factors Hes1, Ascl1 and Oligo2 Exhibit Different Expression Patterns in the Process of Physiological Electric Fields-Induced Neuronal Differentiation

    Mouse embryonic brain NSCs were used to investigate the expression changes of Ascl1, Hes1, and Oligo2 in mRNA and protein levels during electric field-induced neuronal differentiation.
    [Molecular Biology Reports]

    Abstract
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    REVIEWS

    Inflammasomes in Neurological Disorders — Mechanisms and Therapeutic Potential

    The authors present the current evidence for and understanding of inflammasome activation in neurological diseases and discuss current and potential interventional strategies that target inflammasome activation to mitigate its pathological consequences.
    [Nature Reviews Neurology]

    Abstract

    The Role of IL-6 in Neurodegenerative Disorders

    The authors summarize the production and function of IL-6 as well as its downstream signaling pathways. Moreover, they provide a comprehensive review of the roles of IL-6 in neurodegenerative disorders and its potential clinical application.
    [Neurochemical Research]

    Abstract
    INDUSTRY AND POLICY NEWS

    First Brain Organoids Grown from Fetal Tissue Offer Window on Development

    A new and potentially controversial method, growing tiny, brainlike structures called organoids in a dish from human fetal brain tissue, could provide a realistic model and improve the study of developmental disorders or brain cancers.
    [Science]

    Press Release

    Apertura Gene Therapy Unveils Novel Engineered AAV Capsids Targeting Human Transferrin Receptor 1 for Neurological Gene Therapy Delivery

    Apertura Gene Therapy unveiled its proprietary engineered Adeno-Associated Virus (AAV) capsids that bind to the human Transferrin Receptor 1. This transportation mechanism mediates the crossing of the blood-brain barrier to enable gene therapy delivery throughout the central nervous system.
    [Aperture Gene Therapy]

    Press Release
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    JOB OPPORTUNITIES

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    Human Technopole – Milan, Italy

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