 | | Vol. 18.02 – 24 January, 2024 |
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| Researchers showed in mice that latrophilin-3 organized synapses through a convergent dual-pathway mechanism: activation of Gαs signaling and recruitment of phase-separated postsynaptic protein scaffolds.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| High-throughput screening in human pluripotent stem cell-derived dopamine neurons identified several FDA-approved drugs that could rescue the cellular senescence phenotype by preventing SARS-CoV-2 infection.
[Cell Stem Cell] |
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| In a transient middle cerebral artery occlusion (MCAO) mouse model of an ischemic stroke, the authors demonstrated that intravenously injected mIL-10@MLNPs induce IL-10 production and enhance the M2 polarization of microglia.
[ACS Nano] |
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| Using two distinct murine glioma models, researchers examined the role of Trem2 on tumor progression and immune modulation of myeloid cells.
[Neuro-Oncology] |
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| Investigators studied the effects of electrical stimulation of cutaneous afferents on unrelated processing of proprioceptive inputs. They recorded intraspinal neural activity in four monkeys while generating proprioceptive inputs from the radial nerve.
[Cell Reports] |
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| To study mechanisms of pathogenesis for GATA zinc finger domain containing 2B (GATAD2B), scientists characterized a mouse model harboring an inactivating mutation in Gatad2b.
[Translational Psychiatry] |
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| To address whether chondroitin sulphate proteoglycan was significant for hindbrain development, its expression was manipulated in vivo and in vitro.
[Development] |
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| Investigators reported the spatial distribution and functional implications of pleomorphic adenoma gene 1 (PLAG1) expression in the adult mouse brain.
[Molecular Neurobiology] |
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| Scientists confirmed the observed underexpression of miRNA-410 in glioma tissues and several glioma cells by Quantitative RT-PCR. Their findings suggested that epigenetic alterations occurring at the promoter region of miR-410 may be responsible for the reduced expression of miR-410 in glioma.
[Scientific Reports] |
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| The application of 3D and organ-on-a-chip models in neurodegenerative disease research marks a prosperous step forward, providing a more realistic representation of the complex interactions within the neuroimmune system.
[Journal of Neuroinflammation] |
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| A Ludwig Cancer Research study has generated a granular portrait of how the cellular and molecular components of the blood vessels that feed brain metastases of melanoma and lung and breast cancers differ from those of healthy brain tissue.
[EurekAlert] |
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| February 21 – 24, 2024
San Antonio, Texas, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Texas A&M University – College Station, Texas, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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| | Human Technopole – Milan, Italy |
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