 | | Vol. 18.03 – 31 January, 2024 |
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| The authors showed, in mice, that cerebellar projections to the substantia nigra pars compacta (SNc) form monosynaptic glutamatergic synapses with dopaminergic and non-dopaminergic neurons in the SNc.
[Nature Neuroscience] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported numerous denuded axons in the lesion of human brain sections with ischemic stroke, accompanied by decreased neuron density, suggesting neuron loss correlates with myelin deficits in the stroke lesion.
[Brain] |
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| Researchers employed autophagy-targeting chimera (AUTOTAC) to synthesize ATC161, a chimeric compound that adopts Anle138b as target-binding ligand for SNCA aggregates.
[Autophagy] |
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| The authors performed an unbiased proteomic analysis and identified a fibronectin-derived peptide called Anastellin that was unique to the tissue inhibitor of metalloproteinase-1 (TIMP1) knockout astrocyte secretome.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators used integral analysis of chromatin immunoprecipitation-sequencing and RNA sequencing, we reported that RUNX1 positively regulated the expression of various ECM-related genes, including Fibronectin 1, Collagen type IV alpha 1 chain, and Lumican, in glioblastoma.
[Cell Death & Disease] |
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| Scientists reported that conditional deletion of serum response factor (SRF) in adult astrocytes caused reactive-like hypertrophic astrocytes throughout the mouse brain.
[eLife] |
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| Microglia were successfully differentiated from retinoblastoma patient-derived human induced pluripotent stem cells and human embryonic stem cells, and researchers investigated the function of RB1 in microglia by live imaging phagocytosis assay, immunofluorescence, RNA-seq, qRT-PCR, ELISA, and more.
[Glia] |
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| Investigators evaluated the therapeutic effects of desloratadine, a selective 5HTR2A antagonist, in human SOD1G93A (hSOD1G93A) ALS model mice.
[Acta Pharmacologica Sinica] |
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| Scientists analyzed the reaction of glial cells in a highly translational but variable closed-head injury model and were able to correlate the severity of the trauma to the degree of glial response.
[Scientific Reports] |
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| The authors discuss the current knowledge about the vital and dual roles of astrocytes and microglia on the blood–brain barrier breakdown during ischemic stroke.
[Molecular Neurobiology] |
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| West Virginia University has been tapped to help accelerate commercialization of medical innovations by collaborating with a nationwide network within the National Institutes of Health.
[West Virginia University] |
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| University at Albany scientist Scott Tenenbaum has received $500,000 from the National Institute on Aging to study how aging brain cells shape the progression of Alzheimer’s disease and advance RNA technology that could inform new therapeutics to prevent and treat Alzheimer’s and related dementias.
[University at Albany (Newswise)] |
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| March 11 – 13, 2024
Lisbon, Portugal |
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| | King’s College London – London, England, United Kingdom |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Texas A&M University – College Station, Texas, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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