 | | Vol. 18.04 – 7 February, 2024 |
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| Scientists developed a human pluripotent stem cell-based approach to synchronize the birth of cortical neurons in vitro which helped to define an atlas of morphological, functional, and molecular maturation.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators uncovered a role for microglia in the maintenance of structural integrity at two fetal cortical boundaries.
[Cell] |
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| Researchers employed optogenetic methods to stimulate microglia in vitro and in vivo. Membrane depolarization rapidly changed microglia morphology and led to enhanced phagocytosis.
[Neuron] |
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| The authors showed that sonic hedgehog (SHH) inactivated p38α in a smoothened-dependent manner, conversely, p38α directly phosphorylated GLI1 on Ser937/Ser941 to induce GLI1’s proteasomal degradation and negated the transcription of SHH signaling.
[Nature Communications] |
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| Investigators took advantage of TwinF interface inhibition that allowed selective elimination of extrasynaptic NMDA receptor-mediated toxicity via disruption of the NMDAR/TRPM4 death signaling complex while sparing the vital physiological functions of synaptic NMDARs.
[Cell Reports Medicine] |
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| Scientists developed a simple and stable culture method of mouse glial cells, termed mixed-glial culture on/in soft substrate, which served well as a platform to study cancer-glia interactions.
[Developmental Cell] |
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| Investigators showed that genetic ablation of the phospholipase A1 isoform DDHD2 in mice dramatically reduced saturated free fatty acid responses to memory acquisition across the brain.
[EMBO Journal] |
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| Scientists unraveled the multifaceted nature of glaucoma by investigating the interaction between T cells and retinas by utilizing clinical samples, murine glaucoma models, and T cell transfer models.
[Journal of Neuroinflammation] |
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| The authors identified protein differences associated with epilepsy and Alzheimer’s disease using published proteomics datasets.
[Acta Neuropathologica] |
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| Scientists provide the evaluation of the cross-talk between mitochondrial stress and neuroinflammation within the context of stroke.
[Journal of Neuroinflammation] |
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| Neuralink, the company through which entrepreneur Elon Musk hopes to revolutionize brain–computer interfaces, has implanted a ‘brain-reading’ device into a person for the first time.
[Nature] |
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| March 13 – 15, 2024
Vienna, Austria |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | University of Virginia – Charlottesville, Virginia, United States |
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| | King’s College London – London, England, United Kingdom |
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| | Cedars-Sinai – Los Angeles, California, United States |
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