 | | Vol. 18.05 – 14 February, 2024 |
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| Using transcriptomic data, the authors developed transgenic mice to examine specific anatomical structures that function as routes across the arachnoid barrier.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators established a lineage tracing system, leveraging the expression dynamics of secreted phosphoprotein 1 (Spp1) to label and track disease-associated microglia-like microglia during brain injury and recovery.
[Immunity] |
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| Performing deep brainstem recordings of Chx10 gigantocellular (Gi) Ca2+ activity in adult mice, researchers showed that striatal projection neurons initiated turning gaits via a dominant crossed pathway to Chx10 Gi neurons on the contralateral side.
[Nature Neuroscience] |
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| Scientists used spatial transcriptomics to study the ischemic hemisphere in mice after stroke and sequenced the transcriptomes of 19,777 spots, allowing us to both visualize the transcriptional landscape within the tissue and identify gene expression profiles linked to specific histologic entities.
[Science Translational Medicine] |
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| The authors found that RNF220, a known leukodystrophy-related E3 ubiquitin ligase, was required for oligodendroglial development.
[Science Advances] |
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| Researchers generated conditional Cdkl5 knockout mice in excitatory neurons, inhibitory neurons, and astrocytes. To assess CDKL5 activity, they utilized a phosphospecific antibody for phosphorylated EB2, a well-known substrate of CDKL5.
[Molecular Psychiatry] |
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| By generating a CNS-specific armadillo repeat–containing X-linked protein 3 (Alex3) knockout mouse line, investigators demonstrated that Alex3 was required for the effects of Gαq on mitochondrial trafficking and dendritic growth in neurons.
[Science Signaling] |
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| Researchers used CRISPR-Cas9 genome editing to generate a novel series of isogenic iPSC lines deficient in the two most well-validated LRRK2 substrates, RAB8a and RAB10, from deeply phenotyped healthy control lines.
[Stem Cell Reports] |
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| C57BL/6 mice of postnatal day 14 and neural stem cells NE4C were treated with 2% sevoflurane for six hours. Scientists used the Morris water maze to test the cognitive function of infant mice.
[CNS Neuroscience & Therapeutics] |
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| Mitochondria-Endoplasmic Reticulum Contact Sites (MERCS) are dynamic structures whose physiological interaction is vital to direct life and death of the cell. Dysregulation of this interplay leads to various neurodegenerative disorders.
[Molecular Neurobiology] |
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| By squirting cells from a 3D printer, researchers have created tissue that looks—and acts—like a chunk of brain.
[Science] |
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| The 10,000 Brains Project has been launched to promote the ethical use of artificial intelligence (AI) in the fight against Alzheimer’s, Parkinson’s, and other neurodegenerative diseases.
[10,000 Brains Neuro AI, Inc. (PR Newswire)] |
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| March 18 – 19, 2024
London, England, United Kingdom |
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| | Cyprus Cancer Research Institute – Aglandjia, Cyprus |
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| | Cyprus Cancer Research Institute – Aglandjia, Cyprus |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | University of Virginia – Charlottesville, Virginia, United States |
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