 | | Vol. 18.06 – 21 February, 2024 |
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| To explore the emergence and consequences of TDP-43 pathologies, the authors generated induced pluripotent stem cell-derived, colony morphology neural stem cells via manual selection of neural precursors.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that Drosophila glia exhibited a daily cycle of glial mitochondrial oxidation and lipid accumulation that was dependent on prior wake and required the Drosophila APOE orthologs NLaz and GLaz, which mediated neuron–glia lipid transfer.
[Nature Neuroscience] |
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| Researchers reported that O-GlcNAc modification of α-synuclein monomers resulted in the formation of amyloid fibril with distinct core structure, as revealed by cryogenic electron microscopy, and diminished seeding activity in seeding-based neuronal and rodent models of Parkinson’s disease.
[Nature Chemical Biology] |
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| Using a genome-wide screening approach, the authors identified protein phosphatase 2A (PP2A) and glycogen synthase kinase 3 (GSK3) as novel modifiers of fused in sarcoma-amyotrophic lateral sclerosis.
[Acta Neuropathologica] |
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| Researchers reported 20 new recombinant rabies virus vectors that they have developed for multi-scale and multi-modal neural circuit mapping tools.
[Molecular Psychiatry] |
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| Scientists generated stable tau-depleted human induced pluripotent stem cell (iPSC) isogenic panels from two healthy individuals using CRISPR-Cas9 technology. They then differentiated these iPSCs into cortical neurons in vitro in co-culture with primary rat cortical astrocytes.
[Molecular Psychiatry] |
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| To examine how newborn neurons dispersed through the adult brain is unclear, investigators used in vivo two-photon imaging in transgenic zebra finches that expressed GFP in young neurons and other cell types.
[Cell Reports] |
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| Researchers found that MPN domain-containing protein 1 (Mysm1) was expressed in neural stem cells and its expression was increased with age in mice.
[Cell Death & Disease] |
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| Using live-cell microscopy, scientists investigated the role of vacuolar protein sorting 13 homolog C (VPS13C) in regulating lysosomal dynamics and function in human induced pluripotent stem cell-derived dopaminergic neurons.
[Journal of Cell Biology] |
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| The authors present an overview of the current progress in understanding of cellular heterogeneity and tumor origin of medulloblastoma and discuss novel findings in the age of single-cell technologies.
[Oncogene] |
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| Stephanie Gantz, Carver College of Medicine assistant professor in molecular physiology and biophysics, was named one of the 2024 Sloan Research Fellows by the Alfred P. Sloan Foundation.
[The University of Iowa] |
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| March 24 – 29, 2024
Galveston, Texas, United States |
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| | University of Antwerp – Antwerp, Belguim |
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| | University of Southern California – Los Angeles, California, United States |
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| | University of Amsterdam – Amsterdam, Netherlands |
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| | University of Barcelona – Barcelona, Catalonia, Spain |
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| | Cyprus Cancer Research Institute – Aglandjia, Cyprus |
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