 | | Vol. 18.07 – 28 February, 2024 |
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| Researchers demonstrated that the sustained antidepressant-like behavioral effects of (2S,6S)-hydroxynorketamine in repeatedly stressed animal models involved neurobiological changes in the anterior paraventricular nucleus of the thalamus.
[Neuron] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated the mechanism of anti-CD33 antibody HuM195 and its single-chain variable fragment and examined their therapeutic potential.
[Molecular Psychiatry] |
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| Investigators showed that that trisomy manifested as a highly specific modification of the transcriptome within distinct cell types. They observed a significant shift in the transcriptomic profile of granule cells in the dentate gyrus associated with trisomy.
[Molecular Psychiatry] |
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| Scientists combined single-cell transcriptomics of dissected brain regions with massively parallel lineage tracing and in vivo RNA metabolic labeling to analyze the regulation of neural stem cells in space and time.
[Molecular Systems Biology] |
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| The authors showed that conditional disruption of ubiquitin-associated protein 1 (UBAP1), a component of endosomal sorting complex required for transport (ESCRT), caused severe brain dysplasia and prenatal ventriculomegaly.
[Cell Reports] |
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| Investigators utilized a combination of multi-omics data, to identify RFX4 as an upstream regulator of proneural genes. They further validated the role of RFX4 using an in vitro model of neuronal differentiation with RFX4 knock-in and a CRISPR-Cas9 knock-out system.
[Cellular and Molecular Life Sciences] |
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| Scientists used two-photon dendritic calcium imaging and whole-cell electrophysiology to evaluate the role of L-type calcium channels in tonic and phasic dendritic calcium signals in pedunculopontine nucleus and substantia nigra pars compacta neurons.
[European Journal of Neuroscience] |
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| Glial fibrillary acidic protein (GFAP) (post-)transcriptional regulation is likely a mechanism by which radial glia, astrocytes, and glioma cells can modulate cellular function.
[Current Opinion in Cell Biology] |
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| The first person to receive a brain-monitoring device from Neuralink can control a computer cursor with their min. However, researchers say that this is not a major feat — and they are concerned about the secrecy around the device’s safety and performance.
[Nature] |
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| March 21 – 23, 2024
Tokyo, Japan |
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| | Augusta University – Augusta, Georgia, United States |
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| | Cedars Sinai Medical Center – Los Angeles, California, United States |
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| | University of Antwerp – Antwerp, Belguim |
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| | University of Southern California – Los Angeles, California, United States |
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| | University of Amsterdam – Amsterdam, Netherlands |
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