 | | Vol. 18.09 – 13 March, 2024 |
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| Researchers demonstrated that induction of a gliogenic switch in a subset of progenitors enabled the rapid derivation of astroglial cells, which account for 25–31% of the cell population within 8–10 weeks of differentiation.
[Nature Biotechnology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using ex vivo confocal microscopy, investigators analyzed microglial dynamic behaviors in the entorhinal cortex and hippocampus CA1 of 6-, 12-, and 21-month-old mice APOE3 or APOE4 knock-in mice expressing GFP under the CX3CR1 promoter.
[Molecular Neurodegeneration] |
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| Scientists examined the requirement for the catalytic BAF subunit Brahma-related gene 1 (BRG1) in neural progenitor cell specification from human embryonic stem cells.
[Science Advances] |
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| Researchers demonstrated that microglial histone deacetylase (HDAC) 3 knockout ameliorated post-stroke long-term functional and histological outcomes.
[Science Advances] |
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| lncRNAs induced by hypoxia in glioma stem-like cells (GSCs) were identified by RNAseq. LUCAT1 expression was assessed by qPCR, RNAseq, Northern blot, single molecule FISH in GSCs, and interrogated in IvyGAP, TCGA, and CGGA databases.
[Neuro-Oncology] |
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| The authors used ChIP assays to uncover the crosstalk between HIF1α and ATF3 and their roles in P4HA1 regulation. Protein degradation analysis, LC-MS/MS, and in vitro succinate production assays were performed to examine the effect of protein succinylation on glioblastoma pathology.
[Neuro-Oncology] |
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| Researchers investigated the activity of single neurons related to cardiac and respiratory functions in three subcortical regions: ventral intermedius nucleus and ventral caudalis nucleus of the thalamus, and subthalamic nucleus.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors summarize profiles of several major cytosolic DNA sensors and their common adaptor protein STING. They also discuss both the beneficial and detrimental roles of cytosolic DNA sensors in the genesis and progression of neurodegenerative diseases.
[EMBO Molecular Medicine] |
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| HDAX Therapeutics is focused on developing treatments for peripheral nerve damage, which can result from chemotherapy or radiation.
[University of Toronto] |
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| April 4 – 5, 2024
Cincinnati, Ohio, United States |
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| | Zhejiang Chinese Medical University – Zhejiang, China |
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| | The Lundquist Institute – West Carson, California, United States |
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| | Westlake University – Zhejiang, China |
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| | The Institute of Genetics, Molecular and Cellular Biology – Strasbourg-Ville, France |
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