 | | Vol. 18.10 – 20 March, 2024 |
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| Through single-nucleus RNA sequencing of brain tissue in Alzheimer’s disease, researchers have identified a microglial state defined by the expression of the lipid droplet-associated enzyme ACSL1 with ACSL1-positive microglia being most abundant in patients with Alzheimer’s disease having the APOE4/4 genotype.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using a multiomics approach, the authors identified a molecular signature that sustained the activation of microglia through mitochondrial complex I activity driving reverse electron transport and the production of reactive oxygen species.
[Nature] |
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| Investigators performed whole-genome sequencing of 86 single oligodendrocytes, 20 mixed glia, and 56 single neurons from neurotypical individuals spanning 0.4–104 years of age and identified >92,000 somatic single-nucleotide variants and small insertions/deletions.
[Cell] |
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| Researchers documented neuronal activation of the stimulator of interferon genes (STING) pathway in human postmortem cortical and spinal motor neurons from individuals affected by familial or sporadic amyotrophic lateral sclerosis.
[Acta Neuropathologica] |
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| Scientists reported that Scn2a-deficient mice had impaired learning and memory, accompanied by reduced synaptic transmission and lower spine density in neurons of the hippocampus.
[Molecular Psychiatry] |
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| Investigators showed that serum response factor (SRF) was required cell autonomously in oligodendrocytes for myelination during development.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors found that intercellular homotypic N-cadherin interactions differentially regulated glioma migration according to the microenvironment, stimulating migration on cultured neurons or astrocytes but inhibiting invasion into reconstituted or astrocyte-deposited extracellular matrix.
[Journal Of Cell Biology] |
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| Scientists summarize the phenotypes of commonly used as well as newly developed mouse models in translational research laboratories including the presence or absence of key pathological features of Alzheimer’s disease.
[Molecular Neurodegeneration] |
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| The authors explore the interconnected pathogenic features of different types of neurodegenerative disease (ND), discuss the general strategy to modeling NDs using a microfluidic chip, and introduce the organoid-on-a-chip as the next advanced relevant model.
[Nature Communications] |
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| Three recipients, along with their dedicated research teams, received $1.1 million each to advance our understanding of mental health conditions at a fundamental level.
[Brain Canada Foundation] |
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| April 7 – 10, 2024
San Diego, California, United States |
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| | NYU Langone Health – New York City, New York, United States |
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| | Zhejiang Chinese Medical University – Zhejiang, China |
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| | The Lundquist Institute – West Carson, California, United States |
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| | Westlake University – Zhejiang, China |
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