Neural Cell News Volume 18.11 | Mar 27 2024

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    Noshin Noorjahan
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    2024-03-27 | NCN 18.11


    Neural Cell News by STEMCELL Technologies
    Vol. 18.11 – 27 March, 2024
    TOP STORY

    Reactivating PTEN to Impair Glioma Stem Cells by Inhibiting Cytosolic Iron-Sulfur Assembly

    The authors found that PTEN directly interacted with MMS19 and competitively disrupted MMS19-based cytosolic iron-sulfur cluster assembly machinery in differentiated glioma cells.
    [Science Translational Medicine]

    Abstract
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    TGR5-Mediated Lateral Hypothalamus-dCA3-Dorsolateral Septum Circuit Regulates Depressive-Like Behavior in Male Mice

    Using depression models of chronic social defeat stress and chronic restraint stress in male mice, researchers found that TGR5 in the lateral hypothalamic area predominantly decreased in GABAergic neurons, the excitability of which increased in depressive-like mice.
    [Neuron]

    AbstractGraphical Abstract

    Small-Molecule Caspase-1 Inhibitor CZL80 Terminates Refractory Status Epilepticus via Inhibition of Glutamatergic Transmission

    The authors highlighted the therapeutic potential of CZL80, a small molecule that inhibits caspase-1, in status epilepticus termination and its related mechanisms.
    [Acta Neuropathologica]

    Abstract

    Mutant Huntingtin Protein Induces MLH1 Degradation, DNA Hyperexcision, and cGAS–STING-Dependent Apoptosis

    Investigators show that huntingtin (HTT) interacted with both exonuclease 1 (Exo1) and MutLα, a negative regulator of Exo1.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Feedforward and Feedback Mechanisms Cooperatively Regulate Rapid Experience-Dependent Response Adaptation in a Single Thermosensory Neuron Type

    Researchers showed that rapid thermosensory response adaptation in AFD was mediated via cGMP and calcium-dependent feedforward and feedback mechanisms operating at the level of primary thermotransduction.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Glucosylceramide Accumulation in Microglia Triggers STING-Dependent Neuroinflammation and Neurodegeneration in Mice

    Scientists investigated the mechanisms by which glucosylceramide (GC) accumulation induced neuroinflammation. They found that GC accumulation within microglia induced by pharmacological inhibition of GCase triggered STING-dependent inflammation, which contributed to neuronal loss both in vitro and in vivo.
    [Science Signaling]

    Abstract

    Prosaposin Maintains Adult Neural Stem Cells in a State Associated with Deep Quiescence

    Using RNA sequencing and pharmacological manipulations, investigators showed that lysosomes were necessary for neural stem cell quiescence maintenance.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract
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    REVIEWS

    The Dynamics of Notch Signaling in the Neuron-Glia Switch: A Balancing Act

    The author offers several suggestions for future research investigating the precise spatiotemporal control of Notch signaling throughout the development of the central nervous system.
    [Journal Of Neurophysiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Genetically Engineered Marmosets Promise Insight into Early Stages of Parkinson’s

    A cohort of transgenic marmoset models may help predict neurological conditions and test potential treatments.
    [Science]

    Editorial
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