 | | Vol. 18.12 – 3 April, 2024 |
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| Scientists showed that tanycytes were activated upon acute thermal challenge and were necessary to reduce food intake afterwards.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| By combining large-scale neural recordings in mice with dimensionality reduction techniques, investigators observed that successive maze traversals were tracked by continuously drifting populations of neurons, providing neuronal signatures of both places visited and events encountered.
[Science] |
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| Scientists developed a semi-automated live/fixed correlative imaging method to map basal radial glial cell division modes in early fetal tissue and cerebral organoids.
[Nature Cell Biology] |
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| Researchers investigated the interaction of acetylcholine and oxytocin at slow and fast timescales during various brain states.
[Neuron] |
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| The authors showed that m6A methylation was the mechanism that released intron detention and triggered nuclear export, enabling rapid and synchronized responses.
[Nature Communications] |
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| Investigators used single-cell transcriptomics to systematically examine how partial reprogramming influenced the subventricular zone neurogenic niche in aged mouse brains.
[Nature Aging] |
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| Researchers found that antisense oligonucleotides targeting APP are an effective approach to reduce APP protein levels and rescue endolysosome and autophagy dysfunction in APP duplication human induced pluripotent stem cell-derived cortical neurons.
[Brain] |
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| Scientists showed that EREG, encoding the growth factor EPIREGULIN, was expressed in the human developing neocortex and in gorilla cerebral organoids, but not in the mouse neocortex.
[EMBO Journal] |
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| To assess the m6A requirement in motor neurons (MNs), researchers depleted the m6A methyltransferase-like 3 (METTL3) in cells and mice. METTL3 depletion in embryonic stem cell-derived MNs had profound and selective effects on survival and neurite outgrowth.
[Cell Reports] |
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| Scientists outline the hypothesis here that lipopolysaccharide (LPS) may contribute to the pathophysiology of Alzheimer’s disease (AD) via peripheral infections or gut dysfunction elevating LPS levels in blood and brain.
[Molecular Neurodegeneration] |
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| The authors discuss presynaptic perspectives of neurodevelopmental disorders by focusing on impaired axonal transport and disturbed assembly and maintenance of presynapses.
[Journal of Cell Biology] |
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| The Pershing Square Foundation announced the seven winners of the Maximizing Innovation in Neuroscience Discovery (MIND) Prize. Through the Prize, the Foundation strives to change the paradigm of neuroscience research by facilitating a deeper understanding of the brain and cognition.
[Pershing Square Foundation] |
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| April 24 – 26, 2024
Vienna, Austria |
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| | Leibniz Institute for Neurobiology – Magdeburg, Germany |
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| | NYU Langone Health – New York City, New York, United States |
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| | Zhejiang Chinese Medical University – Zhejiang, China |
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| | The Lundquist Institute – West Carson, California, United States |
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