Neural Cell News Volume 18.14 | Apr 17 2024

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    Emily Salmini
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    2024-04-17 | NCN 18.14


    Neural Cell News by STEMCELL Technologies
    Vol. 18.14 – 17 April, 2024
    TOP STORY

    Microglial P2Y6 Calcium Signaling Promotes Phagocytosis and Shapes Neuroimmune Responses in Epileptogenesis

    Researchers demonstrated that P2Y6 signaling impacted multiple aspects of myeloid cell immune function during epileptogenesis.
    [Neuron]

    AbstractGraphical Abstract
    PUBLICATIONSRanked by the impact factor of the journal

    Rare Genetic Variation in Fibronectin 1 (FN1) Protects Against APOEε4 in Alzheimer’s Disease

    Investigators hypothesized that APOEε4 carriers without dementia might carry genetic variations that could protect them from developing APOEε4-mediated Alzheimer’s Disease pathology.
    [Acta Neuropathologica]

    Full ArticlePress Release

    NF1 Mutation-Driven Neuronal Hyperexcitability Sets a Threshold for Tumorigenesis and Therapeutic Targeting of Murine Optic Glioma

    Using mouse models of neurofibromatosis type 1 (NF1)-associated optic pathway glioma, the authors demonstrated that Nf1 mutation induced neuronal hyperexcitability and midkine expression, which activated an immune axis to support tumor growth.
    [Neuro-Oncology]

    Abstract

    GUCY2C Signaling Limits Dopaminergic Neuron Vulnerability to Toxic Insults

    Scientists uncovered a previously unexpected role for the guanylyl cyclase C (GUCY2C)-cyclic guanosine monophosphate signaling axis in controlling mitochondrial dysfunction and toxicity in substantia nigra pars compacta dopaminergic neurons.
    [npj Parkinson’s Disease]

    Full Article

    Insights for Disease Modeling from Single-Cell Transcriptomics of iPSC-Derived Ngn2-Induced Neurons and Astrocytes across Differentiation Time and Co-Culture

    Investigators examined the homogeneity of human-induced pluripotent stem cells (hiPSC) derived neuron (hiPSC-N) and hiPSC derived astrocyte A (hiPSC-A) to their in vivo counterparts, the impact of different lengths of time post Ngn2 induction on hiPSC-N, and the impact of hiPSC-N/hiPSC-A co-culture.
    [BMC Biology]

    Full Article

    An Improved Method for Generating Human Spinal Cord Neural Stem Cells

    Scientists reported further optimization of methods for deriving and sustaining cultures of human spinal cord neural stem cell lines that resulted in improved karyotypic stability while retaining anatomical efficacy in vivo.
    [Experimental Neurology]

    Abstract
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    REVIEWS

    Neurofilaments as Biomarkers in Neurological Disorders — towards Clinical Application

    The authors summarize potential clinical applications of neurofilaments as a biomarker of neuro-axonal damage in a range of neurological disorders, including MS, Alzheimer’s disease, frontotemporal dementia, ALS, traumatic brain injury, and Parkinson’s disease.
    [Nature Reviews Neurology]

    Abstract
    INDUSTRY AND POLICY NEWS

    AviadoBio Announces First Patient Treated in ASPIRE-FTD Clinical Trial Evaluating AVB-101 for Frontotemporal Dementia with GRN Mutations

    AviadoBio announced that the first patient has been treated in the Phase I/II ASPIRE-FTD trial evaluating AviadoBio’s investigational gene therapy, AVB-101, in people with frontotemporal dementia with progranulin gene mutations.
    [AviadoBio]

    Press Release
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