 | | Vol. 18.15 – 24 April, 2024 |
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| To identify super-enhancers driving transcription factor regulators, investigators used all-trans retinoic acid to induce neuroblastoma growth arrest and differentiation.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Microfluidics and two-photon confocal microscopy was applied to screen nanocarriers for transport efficacy and gain mechanistic insights into their interactions with neurons.
[Small] |
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| Scientists used proteomics, genetics, and translation assays in cultured cells and mouse brains to reveal altered translation mediated by loss of the kinase TAOK2 in 16p11.2 deletion models.
[Science Advances] |
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| The authors replicated the altered corticogenesis in the Huntington’s disease (HD) fetal brain using HD patient-derived human cortical organoids.
[Molecular Psychiatry] |
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| Investigators generated five different genomic excisions at the C9orf72 locus in a patient-derived iPSC line and a non-diseased wild-type line, and examined gene expression and pathological hallmarks of C9 frontotemporal dementia/ALS in motor neurons differentiated from these lines.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers demonstrated that a nanocarrier, named The-0504, could cross the blood-brain barrier and specifically deliver the payload to gliomas that expressed high amounts of the ferritin/transferrin receptor TfR1.
[Cell Death & Disease] |
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| Four patient-derived pediatric glioma models were investigated to model rebound growth in vitro based on viable cell counts in response to mitogen-activated protein kinase (MAPK) inhibitor (MAPKi) treatment and withdrawal.
[Journal Of Neuro-Oncology] |
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| The authors provide a comprehensive overview of the mechanisms by which phosphatase and tensin homolog deleted on chromosome 10 (PTEN) regulate activities of different stem cell populations and influence neurological disorders.
[Cell Death & Disease] |
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| Aspen Neuroscience, Inc. announced that the first patient has been dosed in the ASPIRO trial, a Phase I/IIa open label clinical trial to assess safety and tolerability of ANPD001.
[Aspen Neuroscience] |
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| Researchers in the UC Davis College of Biological Sciences have received a grant to study the role of the cerebellum in autism.
[UC Davis Health] |
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| | University of Helsinki – Helsinki, Finland |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Harvard Medical School and Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| | University of Dundee – Dundee, Scotland, United Kingdom |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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