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| To effectively inhibit aerobic glycolysis, increase drug delivery efficiency, and improve drug sensitivity, researchers successfully designed and prepared a novel TMZ nanocapsule for the combined delivery of siPKM2 and TMZ.
[Advanced Materials] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators developed pathogenic tau-specific autophagy based on customized nanochaperone for Alzheimer’s disease treatment.
[Advanced Materials] |
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| Using a combination of transcriptomic, proteomic, and phosphoproteomic analyses, the authors demonstrated that chemoradiation and brain vasculature induced cell transition to a functional state named VC-Resist.
[Nature Communications] |
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| Scientists designed a seven-residue D-TLKIVWC peptide, which not only prevented tau aggregation but also fragmented tau fibrils extracted from Alzheimer’s disease brains to neutralize their seeding ability and protect neuronal cells from tau-induced toxicity.
[Science Advances] |
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| The authors investigated the mitochondrial role of PARKIN during aging and in response to stress by employing a series of conditional Parkin knockout mice.
[npj Parkinson’s Disease] |
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| Scientists demonstrated that Brg1 loss profoundly impaired oligodendrocyte-precursor cell (OPC) differentiation in the brain with a comparatively lesser effect in the spinal cord. BRG1 was critical for OPC remyelination after injury.
[Journal of Cell Biology] |
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|
 | | | The authors summarize the state-of-knowledge about each terminal Schwann cells (TSC) type and explore the opportunities that TSCs provide to treat conditions that afflict peripheral axon terminals.
[Trends In Neurosciences] |
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| Anova Enterprises, Inc. has collaborated with the University of California and Denovo Biopharma to manage a newly awarded $11.8M California Institute for Regenerative Medicine (CIRM) grant to support the development of DB107 in patients with newly diagnosed high-grade glioma.
[Anova Enterprises, Inc.] |
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| June 3 – 6, 2024
Santa Fe, New Mexico, United States |
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| | University of Pittsburgh Medical Center – Pittsburgh, Pennsylvania, United States |
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| | Virginia Tech – Blacksburg, Virginia, United States |
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| | University of Helsinki – Helsinki, Finland |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Harvard Medical School and Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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