Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma Here, researchers use mosaic analysis with double markers in mice to model gliomagenesis by initiating concurrent p53/Nf1 mutations sporadically in neural stem cells. [Cell] A Pericyte Origin of Spinal Cord Scar Tissue Here researchers show that a specific pericyte subtype gives rise to scar-forming stromal cells, which outnumber astrocytes, in the injured spinal cord. [Science] Laminin-332 Coordinates Mechanotransduction and Growth Cone Bifurcation in Sensory Neurons Researchers found that mouse epidermal keratinocytes produce a matrix that is inhibitory for sensory mechanotransduction and that the active molecular component is laminin-332. [Nat Neurosci] Ank3-Dependent SVZ Niche Assembly Is Required for the Continued Production of New Neurons Researchers discovered that the adapter molecule Ankyrin-3 (Ank3) is specifically upregulated in ventricular progenitors destined to become ependymal cells, but not in neural stem cells, and is required for subventricular zone (SVZ) niche assembly through progenitor lateral adhesion. [Neuron] Sumoylation Inhibits α-Synuclein Aggregation and Toxicity Using purified α-synuclein researchers compared the aggregation kinetics of unmodified and modified α-synuclein. [J Cell Biol] Foxp2 Regulates Gene Networks Implicated in Neurite Outgrowth in the Developing Brain Researchers used an integrated functional genomics strategy to robustly define Foxp2-dependent pathways, both direct and indirect targets, in the embryonic brain. [PLoS Genet] Jagged2 Controls the Generation of Motor Neuron and Oligodendrocyte Progenitors in the Ventral Spinal Cord A transcriptome analysis identified the Notch ligand Jagged2 as a Sonic hedgehog-regulated factor transiently expressed in motor neuron progenitors. [Cell Death Differ] Glycogen Synthase Kinase 3β Inhibitors Protect Hippocampal Neurons from Radiation-Induced Apoptosis by Regulating MDM2-p53 Pathway Here researchers show that pretreatment of irradiated HT-22 hippocampal-derived neurons with small molecule inhibitors of glycogen synthase kinase 3β (GSK-3β) SB216763 or SB415286, or with GSK-3β-specific shRNA resulted in accumulation of the p53-specific E3 ubiquitin ligase MDM2. [Cell Death Differ] Comparative Study of Methods for Administering Neural Stem/Progenitor Cells to Treat Spinal Cord Injury in Mice The purpose of the present study was to determine the optimal method of cell transplantation to the spinal cord injury site in terms of grafted cell survival and safety. [Cell Transplant] Optimal Stimulus Shapes for Neuronal Excitation Here researchers show in the Hodgkin & Huxley model of the action potential and in experiments on squid giant axons that spike generation in a neuron can be highly discriminatory for stimulus shape and the optimal stimulus shape is dependent upon inputs to the neuron. [PLoS Comput Biol] |