Neocortical Excitation/Inhibition Balance in Information Processing and Social Dysfunction Here researchers design and use several novel optogenetic tools to causally investigate the cellular E/I balance hypothesis in freely moving mammals, and explore the associated circuit physiology. [Nature] Neuronal Basis of Age-Related Working Memory Decline Study findings reveal the cellular basis of age-related cognitive decline in dorsolateral prefrontal cortex (PFC), and demonstrate that physiological integrity can be rescued by addressing the molecular needs of PFC circuits. [Nature] Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibition To query brain serotonergic neurons in homeostasis, researchers used a neuronal silencing tool, mouse RC::FPDi (based on the synthetic G protein–coupled receptor Di), designed for cell type–specific, ligand-inducible, and reversible suppression of action potential firing. [Science] Direct Reprogramming of Adult Human Fibroblasts to Functional Neurons under Defined Conditions Here researchers show that a combination of a microRNA (miR-124) and two transcription factors (MYT1L and BRN2) is sufficient to directly reprogram postnatal and adult human primary dermal fibroblasts to functional neurons under precisely defined conditions. [Cell Stem Cell] HDAC6 Inhibitors Reverse Axonal Loss in a Mouse Model of Mutant HSPB1–Induced Charcot-Marie-Tooth Disease The findings demonstrate the pathogenic role of α-tubulin deacetylation in mutant HSPB1–induced neuropathies and offer perspectives for using HDAC6 inhibitors as a therapeutic strategy for hereditary axonopathies. [Nat Med] Phagocytic Activity of Neuronal Progenitors Regulates Adult Neurogenesis Here, researchers identify an unexpected phagocytic role for the doublecortin-positive neuronal progenitor cells during adult neurogenesis. [Nat Cell Biol] Persistent Sonic Hedgehog Signaling in Adult Brain Determines Neural Stem Cell Positional Identity Researchers show that sonic hedgehog signaling, resulting in high gli1 levels, occurs in the ventral subventricular zone and is associated with the genesis of specific neuronal progeny. [Neuron] Anatomical Coupling of Sensory and Motor Nerve Trajectory via Axon Tracking It is a long-standing question how developing motor and sensory neuron projections cooperatively form a common principal grid of peripheral nerve pathways relaying behavioral outputs and somatosensory inputs. Here, researchers explored this issue through targeted cell lineage and gene manipulation in mouse, combined with in vitro live axon imaging. [Neuron] Nitric Oxide Is an Activity-Dependent Regulator of Target Neuron Intrinsic Excitability Here, investigators show that glutamatergic synaptic activity modulates target neuron excitability and switches the basis of action potential repolarization from Kv3 to Kv2 potassium channel dominance, thereby adjusting neuronal signaling between low and high activity states, respectively. [Neuron] Neural Stem Cell Gene Therapy Ameliorates Pathology and Function in a Mouse Model of Globoid Cell Leukodystrophy Murine neural stem cells, either naive or genetically modified to express supranormal levels of β-galactocerebrosidase, were transplanted into the brain of Twitcher mice, a murine model of Globoid Cell Leukodystrophy, a severe sphingolipidosis. [Stem Cells] |