Disentangling the Functional Consequences of the Connectivity Between Optic-Flow Processing Neurons Researchers quantified the functional effect of an interaction between two optic-flow processing neurons (Vi and H1) in the fly (Lucilia sericata). [Nat Neurosci] Abstract Structural Correlates of Heterogeneous In Vivo Activity of Midbrain Dopaminergic Neurons Investigators examined how the functional diversity of identified dopaminergic neurons in vivo correlates with differences in somato-dendritic architecture and afferent synaptic organization. [Nat Neurosci] Abstract Direct Leptin Action on POMC Neurons Regulates Glucose Homeostasis and Hepatic Insulin Sensitivity in Mice Researchers have dissected the physiological impact of direct leptin action on proopiomelanocortin (POMC) neurons using a mouse model in which endogenous leptin action on its receptor expression was prevented by a LoxP-flanked transcription blocker, but could be reactivated by Cre recombinase. [J Clin Invest] Abstract HB-EGF Is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration Here scientists report that heparin-binding epidermal-like growth factor (HB-EGF) is rapidly induced in Müller glia residing at the injury site and that pro-HB-EGF ectodomain shedding is necessary for retina regeneration. [Dev Cell] Abstract | Press Release Excitability of Prefrontal Cortical Pyramidal Neurons Is Modulated by Activation of Intracellular Type-2 Cannabinoid Receptors Scientists show that type-2 cannabinoid receptors are located intracellularly in layer II/III pyramidal cells of the rodent medial prefrontal cortex and that their activation results in IP3R-dependent opening of Ca2+-activated Cl– channels. [Proc Natl Acad Sci USA] Abstract Protooncogene Ski Cooperates with the Chromatin-Remodeling Factor Satb2 in Specifying Callosal Neurons Investigators report critical roles for Ski in the maintenance of the neural stem cell pool and the specification of callosal neurons. [Proc Natl Acad Sci USA] Abstract Prolonged Maturation Culture Favors a Reduction in the Tumorigenicity and the Dopaminergic Function of Human ESC-Derived Neural Cells in a Primate Model of Parkinson’s Disease Researchers compared the growth and function of human embryonic stem cells (ESC)-derived cells with different stages of neural differentiation implanted in the brains of primate models of Parkinson’s disease. [Stem Cells] Abstract Exogenous Leukemia Inhibitory Factor Stimulates Oligodendrocyte Progenitor Cell Proliferation and Enhances Hippocampal Remyelination Here researchers identify parenchymal glial progenitors as oligodendrocyte progenitor cells and show that leukemia inhibitory factor delivery stimulates their proliferation through the activation of gp130 receptor signaling within these cells. [J Neurosci] Abstract | Press Release Striatal D2 Receptors Regulate Dendritic Morphology of Medium Spiny Neurons via Kir2 Channels Scientists demonstrate that overexpression of dopamine D2 receptors in medium spiny neurons increases their membrane excitability and decreases the complexity and length of their dendritic arbors. [J Neurosci] Abstract Ror-Family Receptor Tyrosine Kinases Regulate Maintenance of Neural Progenitor Cells in the Developing Neocortex Investigators show that Ror1, Ror2, and their ligand Wnt5a are highly expressed in neocortical neural progenitor cells. [J Cell Sci] Abstract Prolonged Seizure Activity Impairs Mitochondrial Bioenergetics and Induces Cell Death The mechanisms underlying neuronal death following excessive activity such as occurs during prolonged seizures are unclear, but mitochondrial dysfunction has been hypothesized to play a role. Here, researchers tested this with fluorescence imaging techniques in rat glio-neuronal neocortical co-cultures using low magnesium to induce seizure-like activity. [J Cell Sci] Abstract Long-Term Gene Therapy Causes Transgene-Specific Changes in the Morphology of Regenerating Retinal Ganglion Cells Gene therapy holds much promise for the treatment of neurotrauma and neurodegenerative diseases; however, neurotrophic factors are known to alter dendritic architecture, and thus researchers set out to determine whether such transgenes also change the morphology of transduced neurons. [PLoS One] Abstract | Press Release |