MicroRNA-9 Regulates Axon Extension and Branching by Targeting Map1b in Mouse Cortical Neurons Researchers found that microRNA-9 controlled axonal extension and branching by regulating the levels of Map1b, an important protein for microtubule stability. [Nat Neurosci] Abstract Somatic Activation of AKT3 Causes Hemispheric Developmental Brain Malformations Scientists showed that AKT3 is the most abundant AKT paralog in the brain during neurogenesis and that phosphorylated AKT is abundant in cortical progenitor cells. [Neuron] Abstract Neurofibromatosis-Like Phenotype in Drosophila Caused by Lack of Glucosylceramide Extension Researchers found that loss of the glycosyltransferase glycosyltransferase Egghead affects membrane signaling and activation of phosphatidylinositol 3-kinase signaling in glia of the peripheral nervous system, and suggest that glycosyltransferases may suppress proliferation. [Proc Natl Acad Sci USA] Abstract Mitotic Spindle Orientation Can Direct Cell Fate and Bias Notch Activity in Chick Neural Tube Researchers showed that divisions that separate apical and basal components generate an apical daughter, which becomes a neuron, and a basal daughter, which rapidly re-establishes apico-basal polarity and divides again. [EMBO J] Abstract The In Vivo Developmental Potential of Porcine Skin-Derived Progenitors (SKPs) and Neural Stem Cells Researchers investigated the in vivo developmental potential of porcine SKPs and fetal brain-derived neural stem cells by chimera production [Stem Cells Dev] Abstract Gene Expression Profile of Adult Human Olfactory Bulb and Embryonic Neural Stem Cell Suggests Distinct Signaling Pathways and Epigenetic Control Global gene expression profiling was performed using RNA from human embryonic neural stem cells and adult human olfactory bulb-derived neural stem cells to define a gene expression pattern and signaling pathways that are specific for each cell lineage. [PLoS One] Abstract ApoTransferrin: Dual Role on Adult Subventricular Zone-Derived Neurospheres Researchers cultured neural stem and progenitor cells from the rat subventricular zone as neurospheres and studied apoTransferrin effects on oligodendroglial specification and maturation. [PLoS One] Abstract Pilot Study of Induced Pluripotent Stem-Derived Neural Cells to Examine Biologic Effects of Alcohol on Human Neurons In Vitro Researchers used new technologies to reprogram human subject-specific tissue into pluripotent cell colonies and generate human neural cultures as a model system to examine the molecular actions of alcohol. [Alcohol Clin Exp Res] Abstract |