Mutant Presenilin 1 Expression in Excitatory Neurons Impairs Enrichment-Mediated Phenotypes of Adult Hippocampal Progenitor Cells Investigators report that nontransgenic mouse adult hippocampal neural progenitor cells transduced with retroviruses harboring cDNAs that encode either human presenilin 1 (PS1) wild-type or familial Alzheimer’s disease-linked PS1 variants show no differences in environmental enrichment (EE)-mediated proliferation and neuronal differentiation. Moreover, conditional inactivation of a mutant PS1 transgene in type-1 primary progenitor cells failed to rescue impairments of EE-induced proliferation, survival, or neurogenesis. [Proc Natl Acad Sci USA] Abstract Tissue Plasminogen Activator Regulates Purkinje Neuron Development and Survival Scientists found that the homozygous nervous mutant mouse’s 10-fold-increased cerebellar tissue plasminogen activator (tPA), a part of the tPA/plasmin proteolytic system, influences several different molecular mechanisms, each regulating a key aspect of postnatal Purkinje neuron (PN) development, followed by selective PN necrosis. [Proc Natl Acad Sci USA] Abstract | Full Article Upregulation of mGlu2 Receptors via NF-κB p65 Acetylation Is Involved in the Proneurogenic and Antidepressant Effects of Acetyl-L-Carnitine Investigators report that acetyl-L-carnitine (ALC) is a proneurogenic molecule, whose effect on neuronal differentiation of adult hippocampal neural progenitors is independent of its neuroprotective activity. The in vitro proneurogenic effects of ALC appear to be mediated by activation of the NF-κB pathway, and in particular by p65 acetylation, and subsequent NF-κB-mediated upregulation of metabotropic glutamate receptor 2 (mGlu2) expression. [Neuropsychopharmacol] Abstract Serotonin Is Required for Exercise-Induced Adult Hippocampal Neurogenesis Using tryptophan hydroxylase (TPH) 2 deficient (Tph2-deficient) mice that lack brain serotonin, scientists explored the relationship between serotonin signaling and exercise-induced neurogenesis. Surprisingly, Tph2-deficient mice exhibit normal baseline hippocampal neurogenesis but impaired activity-induced proliferation. [J Neurosci] Abstract Bithorax-Complex Genes Sculpt the Pattern of Leucokinergic Neurons in the Drosophila Central Nervous System Researchers aimed to understand the mechanisms by which Hox genes of the Bithorax complex of Drosophila act to define segmental differences in the ventral nerve cord of the central nervous system. To achieve this, they focused on the specification of the leucokinin-expressing neurons. They found that these neurons are specified from the same progenitor neuroblast at two different developmental stages: embryonic and larval neurogenesis. [Development] Abstract Role of Cystatin C in Amyloid Precursor Protein-Induced Proliferation of Neural Stem/Progenitor Cells Researchers examined the role of amyloid precursor protein (APP) in neural stem/progenitor cell (NSPC) proliferation. NSPCs derived from APP-overexpressing Tg2576 transgenic mice proliferated more rapidly than NSPCs from the corresponding background strain wild-type mice. [J Biol Chem] Abstract Stem Cells from Umbilical Cord Wharton’s Jelly from Preterm Birth Have Neuroglial Differentiation Potential Researchers aimed to determine the neuroglial differentiation potential of human Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) from preterm birth when compared to term delivery. Independent of gestational age, a subset of WJ-MSC displayed the neural progenitor cell markers Nestin and Musashi-1 and the mature neural markers microtubule-associated protein 2, glial fibrillary acidic protein, and myelin basic protein. [Reprod Sci] Abstract Inhibitory Effects of Neural Stem Cells Derived from Human Embryonic Stem Cells on Differentiation and Function of Monocyte-Derived Dendritic Cells Researchers used an in vitro approach to evaluate the effects of human neural stem cells (NSCs) on differentiation of human blood CD14+ monocytes into dendritic cells. NSCs derived from H1 human embryonic stem cells and human ReNcell NSC line, as well as human bone marrow derived mesenchymal stem cells, were tested. [J Neuro Sci] Abstract The Phr1 Ubiquitin Ligase Promotes Injury-Induced Axon Self-Destruction Axon degeneration is an evolutionarily conserved process that drives the loss of damaged axons and is an early event in many neurological disorders, so it is important to identify the molecular constituents of this poorly understood mechanism. Scientists demonstrated that the Phr1 E3 ubiquitin ligase is a central component of this axon degeneration program. Loss of Phr1 results in prolonged survival of severed axons in both the peripheral and central nervous systems, as well as preservation of motor and sensory nerve terminals. [Cell Rep] Abstract | Graphical Abstract | Full Article | Press Release Pan-Neuronal Maturation but Not Neuronal Subtype Differentiation of Adult Neural Stem Cells Is Mechanosensitive Researchers cultured adult neural stem cells on variable stiffness ECMs under conditions that promote neuronal fate commitment for extended time periods to allow neuronal subtype differentiation. They found that ECM stiffness does not modulate the expression of NeuroD1 and TrkA/B/C or the percentages of pan-neuronal, GABAergic, or glutamatergic neuronal subtypes. [Sci Rep] Full Article |