Neural Cell News Volume 8.06 | Feb 19 2014

Temporal Identity Transition from Purkinje Cell Progenitors to GABAergic Interneuron Progenitors in the Cerebellum
Findings suggest that the temporal identity transition of cerebellar GABAergic neuron progenitors from Purkinje cell progenitors to Pax2-positive interneuron progenitors is negatively regulated by Olig2 and positively by Gsx1, and contributes to understanding temporal control of neuronal progenitor identities. [Nat Commun] Abstract

Running Rescues Defective Adult Neurogenesis by Shortening the Length of the Cell Cycle of Neural Stem and Progenitor Cells
Investigators showed that running positively affects the cell cycle kinetics of specific subpopulations of newly-generated neurons and suggests that the plasticity of neural stem cells without cell cycle inhibitory control is reactivated by running, with implications for the long-term modulation of neurogenesis. [Stem Cells] Abstract

Jagged1 Is Necessary for Postnatal and Adult Neurogenesis in the Dentate Gyrus
Researchers showed that conditional inactivation of Jagged1 affects neural stem cell maintenance and proliferation during postnatal and adult neurogenesis of the subgranular zone. [Dev Biol] Abstract

Embryonic Cerebrospinal Fluid Nanovesicles Carry Evolutionarily Conserved Molecules and Promote Neural Stem Cell Amplification
Data showed that the embryonic CSF serves as a medium for the distribution of nanovesicles, including exosomes, and the coordinated transfer of evolutionary conserved molecules that regulate embryonic neural stem cell amplification during corticogenesis. [PLoS One] Full Article

Regulatory Roles of miRNA in the Human Neural Stem Cell Transformation to Glioma Stem Cells
To investigate the expressional alternation of microRNAs (miRNA) during the malignant transformation and development of human glioma, researchers measured miRNA expression profile as well as mRNA expression profile in normal human neural stem cells and human glioma stem cells. [J Cell Biochem] Abstract

Serotonin-2C Receptor Involved Serotonin-Induced Ca²⁺ Mobilizations in Neuronal Progenitors and Neurons in Rat Suprachiasmatic Nucleus
The authors generated a subclone of a suprachiasmatic nucleus (SCN) progenitor cell line expressing Ca²⁺ sensors and compared its 5-HT receptor signaling with that of rat SCN neurons in brain slices. [Sci Rep]
Full Article

Posttranscriptional Control of the Stem Cell and Neurogenic Programs by the Nonsense-Mediated RNA Decay Pathway
The mechanisms dictating whether a cell proliferates or differentiates have undergone intense scrutiny, but they remain poorly understood. Researchers report that UPF1, a central component in the nonsense-mediated RNA decay pathway, plays a key role in this decision by promoting the proliferative, undifferentiated cell state. [Cell Rep] Abstract | Full Article | Press Release | Graphical Abstract

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Scripps Florida Team Awarded $2.3 Million to Unlock Mysteries of Long-Term Memory
Scientists from the Florida campus of The Scripps Research Institute have been awarded approximately $2.3 million from the National Institute of Mental Health to study the processes involved in long-term memory and how deficits in those processes contribute to brain diseases. The study focuses on “axonal transport,” the cellular process whereby gene products move to and from a nerve cell body along its axon. [The Scripps Research Institute] Press Release

NEW Stem Cell Summit 2014
April 23-25, 2014
Cambridge, United States