A Quantitative Framework to Evaluate Modeling of Cortical Development by Neural Stem Cells Researchers used transcriptomic analyses to compare in vitro systems to developing human fetal brain and observed strong conservation of in vivo gene expression and network architecture in differentiating primary human neural progenitor cells. They also developed and validated a machine learning approach called CoNTExT that identifies the developmental maturity and regional identity of in vitro models. [Neuron] Abstract Translational Control of mGluR-Dependent Long-Term Depression and Object-Place Learning by eIF2α Scientists describe the translational program that underlies metabotropic glutamate receptor long-term depression (mGluR-LTD) and identify the translation factor eIF2α as its master effector. The findings identify a new model of mGluR-LTD, which promises to be of value in the treatment of mGluR-LTD-linked cognitive disorders. [Nat Neurosci] Abstract | Press Release Autophagy Induction Enhances TDP43 Turnover and Survival in Neuronal ALS Models Investigators show that individual neurons vary in their ability to clear transactive response element DNA-binding protein of 43 kDa (TDP43) and are exquisitely sensitive to TDP43 levels. New compounds that stimulate autophagy improved TDP43 clearance and localization and enhanced survival in primary murine neurons and in human stem cell-derived neurons and astrocytes harboring mutant TDP43. [Nat Chem Biol] Abstract | Press Release TREM2 Mutations Implicated in Neurodegeneration Impair Cell Surface Transport and Phagocytosis Investigators report that missense mutations associated with frontotemporal dementia (FTD) and FTD-like syndrome reduce triggering receptor expressed on myeloid cells 2 (TREM2) maturation, abolish shedding by ADAM proteases, and impair the phagocytic activity of TREM2-expressing cells. [Sci Transl Med] Abstract | Press Release Müller Cells Separate between Wavelengths to Improve Day Vision with Minimal Effect upon Night Vision Researchers show that Müller cells are wavelength-dependent wave-guides, concentrating the green-red part of the visible spectrum onto cones and allowing the blue-purple part to leak onto nearby rods. [Nat Commun] Abstract | Press Release Primary Glioblastoma Cultures: Can Profiling of Stem Cell Markers Predict Radiotherapy Sensitivity? Investigators established stem cell markers and stem cell attributed characteristics such as self-renewal capacity and tumorigenicity have been profiled in primary glioblastoma cultures to predict radiosensitivity. [J Neurochem] Abstract Cell-Based Assays for Parkinson’s Disease Using Differentiated Human LUHMES Cells Given the limited scale of primary dopaminergic neuron culture, researchers developed differentiated Lund human mesencephalic (LUHMES) cell-based cytotoxicity assays for identifying neuroprotective agents for Parkinson’s disease. [Acta Pharmacol Sin] Abstract S-Nitrosylation-Mediated Redox Transcriptional Switch Modulates Neurogenesis and Neuronal Cell Death Scientists report that S-nitrosylation of myocyte enhancer factor 2 (MEF2) transcription factors acts as a redox switch to inhibit both neurogenesis and neuronal survival. S-Nitrosylation disrupts MEF2-DNA binding and transcriptional activity, leading to impaired neurogenesis and survival in vitro and in vivo. [Cell Rep] Full Article | Graphical Abstract | Press Release Focal Transplantation of Human iPSC-Derived Glial-Rich Neural Progenitors Improves Lifespan of ALS Mice Researchers derived glial-rich neural progenitors from human iPSCs and transplanted them into the lumbar spinal cord of amyotrophic lateral sclerosis (ALS) mouse models. The transplanted cells differentiated into astrocytes, and the treated mouse group showed prolonged lifespan. [Stem Cell Rep] Full Article | Graphical Abstract | Press Release |