Pyruvate Kinase and Aspartate-Glutamate Carrier Distributions Reveal Key Metabolic Links between Neurons and Glia in Retina Researchers show that Müller glia in retinas have specific enzyme deficiencies that can enhance their ability to synthesize Gln. The metabolic cost of these deficiencies is that they impair the Müller cell’s ability to metabolize Glc. They demonstrate that the cells can compensate for this deficiency by using metabolites produced by neurons. [Proc Natl Acad Sci USA] Abstract Neurotrophin-3 Regulates Ribbon Synapse Density in the Cochlea and Induces Synapse Regeneration after Acoustic Trauma Using cell-specific inducible gene recombination in mice researchers found that, in the postnatal inner ear, brain derived neurotrophic factor and neurotrophin-3 are required for the formation and maintenance of hair cell ribbon synapses in the vestibular and cochlear epithelia, respectively. They also show that supporting cells in these epithelia are the key endogenous source of the neurotrophins. [eLife] Full Article | Press Release Alternative Generation of CNS Neural Stem Cells and PNS Derivatives from Neural Crest Derived Peripheral Stem Cells Using global gene expression analysis the authors demonstrate that reprogrammed neural crest-derived stem cells completely lose their previous PNS characteristics and acquire the identity of neural stem cells derived from embryonic spinal cord. [Stem Cells] Abstract Adult Neural Precursor Cells from the Subventricular Zone Contribute Significantly to Oligodendrocyte Regeneration and Remyelination The relative contribution of neural precursor cells versus parenchymal oligodendrocyte progenitor cells to remyelination is unknown. Scientists used in vivo genetic fate mapping to assess the behavior of each progenitor type within the corpus callosi of mice subjected to cuprizone-induced demyelination. [J Neurosci] Abstract Notch Signaling Acts before Cell Division to Promote Asymmetric Cleavage and Cell Fate of Neural Precursor Cells The author found that inactivation of Notch in fly embryonic neural precursor cells disrupted the asymmetric positioning of the cleavage furrow and produced daughter cells of the same size and fate. [Sci Signal] Abstract Reprogramming the Fate of Human Glioma Cells to Impede Brain Tumor Development One potential approach to eradicating glioma cells is to force these cells to undergo terminal differentiation and, in the process, to irreversible postmitotic arrest. Investigators show that neurogenin 2 synergizes with sex-determining region Y-box 11 to efficiently convert human glioma cells to terminally differentiated neuron-like cells in both cell culture and adult mouse brains. [Cell Death Dis] Full Article Effects of Let-7b and TLX on the Proliferation and Differentiation of Retinal Progenitor Cells In Vitro The authors show that let-7b and TLX play important roles in controlling retinal progenitor cell (RPC) fate determination in vitro. Let-7b suppresses TLX expression to negatively regulate RPC proliferation and accelerate the neuronal and glial differentiation of RPCs. [Sci Rep] Full Article Functional Regeneration of Supraspinal Connections in a Patient with Transected Spinal Cord following Transplantation of Bulbar Olfactory Ensheathing Cells with Peripheral Nerve Bridging A patient’s olfactory bulb was removed and used to derive a culture containing olfactory ensheathing cells and olfactory nerve fibroblasts. Following resection of the glial scar the cultured cells were transplanted into the spinal cord stumps above and below the patient’s spinal cord injury. [Cell Transplant] Full Article | Press Release Neural-Competent Cells of Adult Human Dermis Belong to the Schwann Lineage Scientists investigated the source of human dermal neural precursor cells in adult tissue. By following an unbiased, comprehensive approach employing cell-surface marker screening, cell separation, transcriptomic characterization, and in vivo fate analyses, they found that p75NTR+ precursors of human foreskin can be ascribed to the Schwann and perivascular cell lineages. [Stem Cell Rep] Full Article | Graphical Abstract |