The Adhesion G Protein-Coupled Receptor ​GPR56 Is a Cell-Autonomous Regulator of Oligodendrocyte Development Scientists demonstrate that loss of ​Gpr56 leads to hypomyelination of the central nervous system in mice. ​GPR56 levels are abundant throughout early stages of oligodendrocyte development, but are downregulated in myelinating oligodendrocytes. [Nat Commun] Full Article | Press Release An Aberrant Sugar Modification of BACE1 Blocks its Lysosomal Targeting in Alzheimer’s Disease Researchers show that β-site amyloid precursor protein cleaving enzyme-1 (BACE1) is modified with bisecting N-acetylglucosamine (GlcNAc), a sugar modification highly expressed in brain, and demonstrate that Alzheimer’s disease patients have higher levels of bisecting GlcNAc on BACE1. [EMBO Mol Med] Full Article | Press Release Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression Researchers provide insight about the effects of prolonged Ezh2 inhibition in glioblastoma using preclinical mouse models and primary tumor-derived human glioblastoma cell lines. [Cell Rep] Full Article | Graphical Abstract Rapid and Efficient Direct Conversion of Human Adult Somatic Cells into Neural Stem Cells by HMGA2/let-7b Using microRNA expression profile analyses, researchers showed that let-7 microRNA has critical roles for the formation of PAX6/NESTIN-positive colonies from human adult fibroblasts and the proliferation and self-renewal of human induced neural stem cells. [Cell Rep] Full Article | Graphical Abstract Stromal SLIT2 Impacts on Pancreatic Cancer-Associated Neural Remodeling Scientists showed that cancer-associated fibroblast-secreted SLIT2 increases neurite outgrowth from dorsal root ganglia neurons as well as from Schwann cell migration/proliferation by modulating N-cadherin/β-catenin signaling. [Cell Death Dis] Full Article Astrocytes Increase ATP Exocytosis Mediated Calcium Signaling in Response to Microgroove Structures A high throughput microscale platform was developed to study astrocyte cell behavior on micropatterned surfaces containing 1 μm spacing grooves with a depth of 250 or 500 nm. Significant changes in cell and nuclear elongation and alignment on patterned surfaces were observed, compared to on flat surfaces. [Sci Rep] Full Article Damage Effect of Interleukin (IL)-23 on Oxygen-Glucose Deprived Cells of the Neurovascular Unit via IL-23 Receptor Scientists explored the potential effect of IL-23 on cells of the neurovascular unit under an oxygen-glucose deprivation condition and the role of IL-23R in IL-23-mediated effect. [Neuroscience] Abstract Brain Pericyte-Derived Soluble Factors Enhance Insulin Sensitivity in GT1-7 Hypothalamic Neurons Scientists investigated whether brain pericytes could affect hypothalamic neuronal insulin signaling. Pericyte-conditioned medium, but not astrocyte- or aortic smooth muscle cell-conditioned medium, increased the insulin-stimulated phosphorylation of Akt in GT1-7 cells in a concentration-dependent manner. [Biochem Biophys Res Commun] Abstract EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner Researchers demonstrate that the catalytic subunit of Polycomb repressive complex 2, EZH2, is targeted by the MELK-FOXM1 complex, which in turn promotes resistance to radiation in glioblastoma-derived tumorigenic stem-like cells. [Stem Cell Rep] Full Article |