Thirst Driving and Suppressing Signals Encoded by Distinct Neural Populations in the Brain Investigators identified two distinct, genetically separable neural populations in the subfornical organ that trigger or suppress thirst. [Nature] Abstract | Press Release Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit Using traumatic injury as a model, scientists systematically investigated mitogen-activated protein kinase (MAPK) families and delineate a MAPK cascade that represents the early degenerative response to axonal injury. [Cell] Abstract | Graphical Abstract | Press Release High Salt Intake Increases Blood Pressure via BDNF-Mediated Downregulation of KCC2 and Impaired Baroreflex Inhibition of Vasopressin Neurons Researchers show that chronic high salt intake impairs baroreceptor inhibition of rat vasopressin neurons through a brain-derived neurotrophic factor (BDNF)-dependent activation of TrkB receptors and downregulation of KCC2 expression, which prevents inhibitory GABAergic signaling. [Neuron] Abstract | Press Release IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior To explore how anti-inflammatory cytokine signaling affects Aβ pathology, scientists investigated the effects of adeno-associated virus-mediated expression of interleukin-10 in the brains of APP transgenic mouse models. [Neuron] Abstract | Press Release Dysregulation of miR-34a Links Neuronal Development to Genetic Risk Factors for Bipolar Disorder Scientists show that levels of microRNA (miR)-34a, which is predicted to target multiple genes implicated as genetic risk factors for bipolar disorder (BD), are increased in postmortem cerebellar tissue from BD patients, as well as in BD patient-derived neuronal cultures generated by reprogramming of human fibroblasts into induced neurons or into induced pluripotent stem cells subsequently differentiated into neurons. [Mol Psych] Abstract Astrocytic Adenosine Receptor A2A and Gs-Coupled Signaling Regulate Memory Researchers found that humans with Alzheimer’s disease had increased levels of the Gs-coupled adenosine receptor A2A in astrocytes. [Nat Neurosci] Abstract | Press Release The Transcription Factor Nerfin-1 Prevents Reversion of Neurons into Neural Stem Cells Researchers show that the Drosophila zinc finger transcription factor nervous fingers 1 (Nerfin-1) locks neurons into differentiation, preventing their reversion into neuroblasts. Following prospero-dependent neuronal specification in the ganglion mother cell, a Nerfin-1-specific transcriptional program maintains differentiation in the post-mitotic neurons. [Genes Dev] Abstract | Press Release The Adhesion GPCR Gpr56 Regulates Oligodendrocyte Development via Interactions with Gα12/13 and RhoA Investigators used zebrafish and mouse models to dissect the function of the adhesion class of G protein-coupled receptor Gpr56 in oligodendrocyte development. They show that gpr56 is expressed during early stages of oligodendrocyte development. [Nat Commun] Abstract | Press Release PACT/RAX Regulates the Migration of Cerebellar Granule Neurons in the Developing Cerebellum Researchers investigated the expression of RAX during the postnatal development of the mouse cerebellum and its role in the migration of cerebellar granule neurons. [Sci Rep] Full Article Ethanol Deregulates Mecp2/MeCP2 in Differentiating Neural Stem Cells via Interplay between 5-Methylcytosine and 5-Hydroxymethylcytosine at the Mecp2 Regulatory Elements To study the effect of ethanol on methyl CpG binding protein 2 (Mecp2)/MeCP2 expression during neurodifferentiation, scientists established an in vitro model of ethanol exposure, using differentiating embryonic brain-derived neural stem cells. [Exp Neurol] Abstract Investigating the Neuro-Glial Differentiation Effect of Neuroblastoma Conditioned Medium in Human Endometrial Stem Cells Cultured on 3D Nanofibrous Scaffold Researchers investigated the differentiation ability of human endometrial stem cells cultured on polylactic acid/chitosan nanofibrous scaffold into neuro-glial cells in response to conditioned medium of BE(2)-C human neuroblastoma cells and growth factors. [J Biomed Mater Res A] Abstract |