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| In human small intestinal organoids, enterocytes were readily infected by SARS-CoV and SARS-CoV-2, as demonstrated by confocal and electron microscopy.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To investigate the pathogenetic mechanisms of mitochondrial presequence processing, researchers employed cortical neurons and cerebral organoids generated from pitrilysin metallopeptidase 1-knockout human iPSCs.
[Molecular Psychiatry] |
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| Investigators conducted a Phase Ib, placebo-controlled, randomised clinical trial of two dose levels of naproxen sodium administered daily for six months to 80 participants with Lynch syndrome (LS), and a co-clinical trial using a genetically engineered mouse model of LS and patient-derived organoids
[Gut] |
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| Using ex vivo and in vivo models of metastasis, scientists established that keratin-14+ breast cancer cells were vulnerable to natural killer cells.
[Journal of Cell Biology] |
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| Investigators tested conditioned media of individual patient-derived organoids (PDOs) for cell-free tumor DNA to detect driver mutations already early on during the expansion process in order to accelerate the genetic characterization of PDOs as well as subsequent functional testing.
[JCI Insight] |
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| To assess the safety of and protection conferred by Nissle, researchers modeled infection in stem cell-derived human intestinal organoids.
[American Society for Microbiology] |
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| The authors showed that CDK5 regulatory subunit-associated protein 3 (CDK5RAP3) was weakly expressed in gastric cancer stem-like cells (CSCs) and was negatively correlated with the gastric CSC marker CD44.
[British Journal of Cancer] |
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| Researchers investigated the transcriptomes of jejunum organoids derived from the same pig as well as batch-to-batch variation of organoids derived from different pigs over long-term passage.
[Frontiers in Cell and Developmental Biology] |
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| Mice ileum organoids were used to evaluate the long‐term effects of grape‐seed proanthocyanidin extract and two of its main components, epicatechin and gallic acid, on intestinal differentiation.
[Molecular Nutrition & Food Research] |
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| Barrett’s esophagus patient biopsies and murine Barrett’s esophagus organoids were cultured ex vivo in the presence of a caspase-1 inhibitor, to determine the importance of caspase-1 for inflammatory cytokine and chemokine secretion.
[Cancer Immunology Immunotherapy] |
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| Scientists demonstrated that GBM associated gene regulatory modules were characterized by diagnostic quiescent stem cell marker genes.
[Scientific Reports] |
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| CRISPR/cas9-mediated mutations of major components of the menin-MLL complex, Men1, Kmt2a and Ash2l, inhibited the growth of tumor organoids, suggesting that the complex was the target of MI-136.
[Cancer Gene Therapy] |
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| The authors discuss the applications, advantages and disadvantages of human organoids as models of development and disease and outline the challenges that have to be overcome for organoids to be able to substantially reduce the need for animal experiments.
[Nature Reviews Molecular Cell Biology] |
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| Since higher education institutions ended in-person classes in March due to the COVID-19 pandemic, there has been uncertainty over what classes will look like in the fall. Universities will soon have to come up with an answer.
[The Scientist]
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| The new director of the National Science Foundation (NSF), Sethuraman “Panch” Panchanathan, is familiar with the dark clouds over the agency. His boss, President Donald Trump, keeps proposing big cuts to NSF’s budget. Two recent executive orders on immigration make it harder for foreign scientists—who make up a sizeable share of the U.S. research enterprise—to enter the country.
[Science] |
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| The Pershing Square Foundation announced that it has awarded $3 million to nineteen recipients at ten academic research institutions conducting research related to the SARS-CoV-2 virus.
[The Pershing Square Foundation] |
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| September 8 – September 11
Virtual |
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| | Human Technopole Foundation – Milan, Italy |
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| | Research Center for Molecular Medicine – Vienna, Austria |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Research Center for Molecular Medicine – Vienna, Austria |
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| | Novo Nordisk Research Centre Oxford – Oxford, United Kingdom |
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| | Philipps-Universität Marburg – Marburg, Germany |
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