Organoid News Volume 1.01 | July 16 2020

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    ON 1.01 | July 16 2020


    Organoid News by STEMCELL Technologies
    Vol. 1.01 – 16 July, 2020
    TOP STORY

    Fasting-Mimicking Diet and Hormone Therapy Induce Breast Cancer Regression

    Researchers showed that in mouse models of hormone-receptor-positive breast cancer, periodic fasting or a fasting-mimicking diet enhanced the activity of the endocrine therapeutics tamoxifen and fulvestrant.
    [Nature]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Persistence of a Regeneration-Associated, Transitional Alveolar Epithelial Cell State in Pulmonary Fibrosis

    Using lung organoids, multiple in vivo repair models, single-cell transcriptomics and lineage tracing, researchers found that alveolar type-2 epithelial cells undergoing differentiation into type-1 cells acquired pre-alveolar type-1 transitional cell state en route to terminal maturation.
    [Nature Cell Biology]

    Abstract

    STING Differentially Regulates Experimental GVHD Mediated by CD8 Versus CD4 T Cell Subsets

    The authors demonstrated that stimulator of interferon genes (STING) signaling in nonhematopoietic cells promoted MHC-matched allogeneic hematopoietic stem cell transplantation–induced GVHD and that STING agonists increased type I interferon and MHC I expression in nonhematopoietic mouse intestinal organoid cultures.
    [Science Translational Medicine]

    Abstract

    Mechano-Modulatory Synthetic Niches for Liver Organoid Derivation

    Investigators demonstrated the establishment of biopsy-derived human liver organoids without the use of animal components at any step of the process. Their approach opens up exciting perspectives for the establishment of protocols for liver organoid-based regenerative medicine.
    [Nature Communications]

    Full Article

    Patient-Specific Alzheimer-Like Pathology in Trisomy 21 Cerebral Organoids Reveals BACE2 as a Gene Dose-Sensitive AD Suppressor in Human Brain

    Scientists report Alzheimer’s disease-like pathology in cerebral organoids grown in vitro from non-invasively sampled strands of hair from 71% of Down Syndrome donors.
    [Molecular Psychiatry]

    Full Article

    Evidencing a Pancreatic Ductal Adenocarcinoma Subpopulation Sensitive to the Proteasome Inhibitor Carfilzomib

    Researchers selected a transcriptomic signature that predicted Carfilzomib chemosensitivity using independent component analysis on the transcriptome of pancreatic ductal adenocarcinoma (PDAC)-derived primary cells cultures. They validated the signature in an independent cohort of PDAC biopsy-derived pancreatic organoids.
    [Clinical Cancer Research]

    Abstract

    The Synthetic Small Molecule FL3 Combats Intestinal Tumorigenesis via Axin1-Mediated Inhibition of Wnt/Beta-Catenin Signaling

    Scientists demonstrated that FL3 combats intestinal tumorigenesis in the azoxymethane-dextran sodium sulfate and ApcMin/+ mouse models and in human colorectal cancer tumor organoids by inhibiting Wnt/beta-catenin signaling via induction of Axin1 expression.
    [Cancer Research]

    Abstract

    A Tissue-Engineered 3D Microvessel Model Reveals the Dynamics of Mosaic Vessel Formation in Breast Cancer

    Investigators developed a tissue-engineered model containing a physiologically realistic microvessel in co-culture with mammary tumor organoids.
    [Cancer Research]

    Abstract

    Dissecting Cell Type-Specific Metabolism in Pancreatic Ductal Adenocarcinoma

    Pancreatic cancer cells exhibited increased pyruvate carboxylation relative to fibroblasts, and this flux depended on both pyruvate carboxylase and malic enzyme 1 activity.
    [eLife]

    Abstract

    Testicular Organoid Formation Is a Property of Immature Somatic Cells, which Self-Assemble and Exhibit Long-Term Hormone-Responsive Endocrine Function

    In murine organoids cultured for 14 days, tubule-like structures exhibiting a highly biomimetic architecture were characterized, including some rare germ and spermatogonial stem cells.
    [Biofabrication]

    Abstract

    Cerebral Organoids As Tools to Identify the Developmental Roots of Autism

    Researchers suggested that cerebral organoids, in their current form, are most suitable to model earlier neurodevelopmental events and processes such as neurogenesis and cortical lamination.
    [Molecular Autism]

    Full Article

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    REVIEWS

    3D Brain Organoids: Studying Brain Development and Disease Outside the Embryo

    Scientists consider the biology of brain organoids, compared and contrasted with the endogenous human brain, and highlight experimental strategies to use organoids to pioneer new understanding of human brain pathology.
    [Annual Review of Neuroscience]

    Abstract

    Organoid Models of Tumor Immunology

    Researchers present a viewpoint on recent advances, and propose translational applications of tumor organoids for immuno-oncology research, immunotherapy modeling, and precision medicine.
    [Trends in Immunology]

    Full Article

    Intestinal Organoids As Tools for Enriching and Studying Specific and Rare Cell Types: Advances and Future Directions

    The authors highlight how new cell type-enriched intestinal organoids can be used to answer a diversity of questions relevant to human biology and disease.
    [Journal of Molecular Cell Biology]

    Full Article

    Tumor Organoids to Study Gastroesophageal Cancer: A Primer

    Scientists explore the development and basic techniques for organoid generation, and discuss the current and potential future applications of this exciting technology to study the basic science of carcinogenesis.
    [Journal of Molecular Cell Biology]

    Full Article

    INDUSTRY AND POLICY NEWS

    During the Pandemic, Students Do Field and Lab Work without Leaving Home

    Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences.
    [Science Insider]

    Editorial

    Open-Access Plan S to Allow Publishing in Any Journal

    Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing.
    [Nature News]

    Editorial

    An Analysis of Ways to Decarbonize Conference Travel after COVID-19

    The COVID-19 pandemic has forced us to rethink what constitutes necessary travel. Many of this year’s conferences have been cancelled. Some have gone virtual. Nature presents an original analysis of the potential emissions savings of doing things differently.
    [Nature News]

    Editorial

    FEATURED EVENT

    2020 Parenteral Drug Association (PDA) Annual Meeting

    July 20 – July 22
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    JOB OPPORTUNITIES

    Postdoctoral Position – Pluripotent Stem Cell-Derived Human Lung Organoids

    Columbia University Medical Center – New York, New York, United States

    Research Group Leaders – Experimental Neurobiology and Brain Organoids

    Human Technopole Foundation – Milan, Italy

    Research Scientist – CRISPR Technology and Organoids

    Research Center for Molecular Medicine – Vienna, Austria

    CeMM International Postdoctoral Program – Immune-Enriched Organoids

    Research Center for Molecular Medicine – Vienna, Austria

    Independent Group Leader – Organoid Cultures

    Philipps-Universität Marburg – Marburg, Germany

    > See All Jobs

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