 | | Vol. 1.05 – 13 August, 2020 |
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| Targeting the mitochondrial pyruvate carrier promoted alanine oxidation to mitigate deoxysphingolipid synthesis and improved spheroid growth.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated mechanisms by which PAF1 maintained cancer stem cells and contributed to development of pancreatic tumors.
[Gastroenterology] |
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| Cortical brain organoid modeling showed reduced proliferation of radial glial cells, leading to smaller organoids characteristic of microcephaly.
[Nature Communications] |
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| Brain organoids derived from iPSCs of patients are a powerful avenue to investigate the pathophysiological processes. Scientists generated iPSC-derived cerebral organoids from monozygotic twins discordant for psychosis.
[Molecular Psychiatry] |
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| Loss of function studies of PIAS1 and TIF1γ suggested that these E3 ligases act in an interdependent manner to suppress epithelial–mesenchymal transition of breast cell-derived tissue organoids. The authors unveiled a novel mechanism by which SUMO E3 ligases coordinate substrate SUMOylation with biological implications.
[Cell Death & Differentiation] |
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| BRAFV600E induced a fetal-like dedifferentiation transcriptional program in colonic organoids, which resembled human BRAFV600E-driven colorectal cancer.
[Oncogene] |
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| Scientists report that physiologically relevant oxygen concentration, an important environmental thymic factor promotes differentiation of cord blood CD34+ cells into progenitor T cells in serum‐free and feeder‐free culture system. This effect was enhanced by a potent reducing and antioxidant agent, ascorbic acid.
[Stem Cells] |
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| To determine the functional impact of increased ST6Gal-I, researchers generated human gastric antral organoids from epithelial stem cells and differentiated epithelial monolayers from gastric organoids.
[Journal of Biological Chemistry] |
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| During 3D organoid formation, the origin of iPSCs affected the levels of FOXA2 and LMX1A only in the first stages of neural differentiation, whereas in the 2D model, differences were detected at the levels of both early and late neural markers.
[International Journal of Molecular Sciences] |
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| When adipose-derived stromal/stem cells (ASC) spheroid cultured in 3D were compared with ASCs cultured in a 2D monolayer, the cell survival and chondrogenic potential were enhanced while the apoptosis was reduced in ASC spheroids.
[Journal of Biomedical Materials Research Part A] |
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| The authors provide a brief introduction to the three most commonly utilized humanized mouse models for the study of gammaherpesvirus-driven pathogenesis.
[Current Opinion in Virology] |
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| Researchers focus on stem cell-based in vitro modeling of neurodevelopmental disorders, more specifically, the fundamentals and technical advancements in monolayer neuron and brain organoid cultures.
[Archives of Pharmacal Research] |
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| CurePSP has awarded a $100,000 grant for a potentially breakthrough study that will employ 3D organoid models that have been shown to produce structures similar to those seen in the human brain to understand the effects of protein mutations that are associated with neurodegeneration.
[CurePSP] |
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| February 28 – March 4 2021
Baden-Württemberg, Germany |
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| | University Medical Centre Groningen (UMCG) – Groningen, Netherlands |
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| | Icahn School of Medicine, Mount Sinai – New York City, New York, United States |
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| | Wellcome Sanger Institute – Cambridge, United Kingdom |
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| | Institut Mondor de Recherche Biomédicale (IMRB) – Creteil, France |
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| | Wayne State University – Detroit, Michigan, United States |
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