 | | Vol. 1.06 – 20 August, 2020 |
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| Researchers generated human islet-like organoids from induced pluripotent stem cells and showed that non-canonical WNT4 signaling drove the metabolic maturation necessary for robust ex vivo glucose-stimulated insulin secretion.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that KRASG13D mutants were sensitive to EGFR inhibition, while KRASG12C mutant organoids were selectively responsive to covalent G12C inhibitors only when EGFR was suppressed.
[Cancer Discovery] |
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| Researchers designed and engineered water-soluble, Frizzled (Fzd) subtype-specific “next-generation surrogate” Wnts that hetero-dimerize Fzd and Lrp6.
[Cell Stem Cell] |
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| Researchers present dynamic full-field optical coherence tomography as a technique to noninvasively image living human iPSC-derived retinal organoids.
[Light-Science & Applications] |
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| Genetic and chemical inhibition of DOT1L selectively impaired the viability of androgen receptor-positive prostate cancer cells and organoids, including castration-resistant and enzalutamide-resistant cells.
[Nature Communications] |
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| Scientists report that high dietary linoleic acid promoted colorectal carcinogenesis in mice treated with azoxymethane or with an intestinally targeted Apc mutation by upregulating Wnt receptor LRP5 protein expression and β-catenin activation.
[Cell Reports] |
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| In vitro, glial cell‐derived neurotrophic factor (GDNF) treatment amplified Wnt signal and increased serotonin levels in colonic organoids in a dose‐dependent manner.
[Cell Proliferation] |
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| Investigators clarified that inhibition of Activin receptor-like kinase signaling was essential for the induction of human salivary gland-derived organoids and showed their usefulness as an inflammatory disease model.
[Disease Models & Mechanisms] |
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| Scientists showed that ablation of tuberous sclerosis complex 2, a negative regulator of mammalian target of rapamycin complex 1 (mTORC1), specifically in intestinal epithelial cells of mice resulted in increased activity of mTORC1 of, as well as increased proliferative activity of, colonic epithelial cells.
[Scientific Reports] |
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| The authors describe multidisciplinary approaches for creating organoid models of human genetic, neoplastic, immunological and infectious diseases.
[Nature Materials] |
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| The authors explore and discuss the diverse animal, cell and tissue models that are being used and developed and collectively recapitulate many critical aspects of disease manifestation in humans to develop and test new preventions and treatments.
[Mucosal Immunology] |
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| Scientists describe recent advances in organoid technologies and their application to cancer biology, clinical translation and precision medicine.
[Nature Cancer] |
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| For patients who’ve run out of other options, experimental, unproven therapies like stem cell treatments offer new hope. But how do you sort the scientifically legitimate from the dangerous?
[STAT News] |
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| November 2 – November 3
Virtual |
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| | Pennsylvania State University – Philadelphia, Pennsylvania, United States |
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| | Institut Mondor de Recherche Biomédicale (IMRB) – Creteil, France |
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| | Wayne State University – Detroit, Michigan, United States |
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| | Icahn School of Medicine, Mount Sinai – New York City, New York, United States |
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| | University Medical Centre Groningen (UMCG) – Groningen, Netherlands |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
