 | | Vol. 1.07 – 27 August, 2020 |
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| Researchers showed that the ablation of luminal cells reactivated the multipotency of basal stem cells from multiple epithelia both in vivo in mice and in vitro in organoids.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists performed single-cell RNA-sequencing, mass spectrometry, and microbiome profiling of intestinal tissues from wildtype and ATOH1-knockout mice, which have expansion of tuft cells, to study interactions between microbes and tuft cell populations. They assessed microbe dependence on these populations using microbiome depletion, organoids, and microbe transplant experiments.
[Gastroenterology] |
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| Investigators showed in gut epithelial cells, that galectin-9 was enriched in lysosomes and predominantly bound to lysosome-associated membrane protein 2 (Lamp2) in a Asn-glycan dependent manner.
[Nature Communications] |
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| Bulk and single-cell RNA sequencing showed that dorsal root ganglia (DRG) organoids present a transcriptional signature similar to native DRGs and displayed the main peripheral sensory neuronal and glial cell subtypes.
[Nature Communications] |
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| Given that endothelial cells (ECs) possess organ-specific gene expression, morphology, and function, investigators used bulk RNA-seq and scRNA-seq to interrogate the developing human intestine, lung, and kidney in order to identify organ-enriched EC gene signatures.
[Developmental Cell] |
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| Employing murine cochlear organoid and explant cultures to model mitotic and nonmitotic mechanisms of hair cell generation, researchers showed that loss of LIN28B function suppressed Akt-mTOR complex 1 activity and rendered young, immature supporting cells incapable of generating hair cells.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists demonstrated that the tumorigenic subpopulation of mouse LGR5+ cells existed in a slow-cycling state and identified a unique 22-gene signature that characterized these slow-cycling cancer stem cells.
[Cancer Research] |
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| Researchers found that the TCF7L2 E-isoforms maintained, whereas the M and S isoforms disrupted morphogenesis of 3D-epithelial cell-derived organoids via regulation of epithelial-mesenchymal transition.
[Cell Death & Disease] |
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| Intestinal epithelial cell (IEC) organoids have increased expression of the type I interferon (IFN) receptor relative to neonate IECs, and the response of IEC organoids to type I IFN was strikingly increased in magnitude and scope relative to type III IFN.
[Journal of Virology] |
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| Investigators report the establishment of endometrial gland organoids from decidua isolated from term placental membranes.
[Placenta] |
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| The authors review the complex mechanical behaviors of tissues and extracellular matrices (ECMs), discuss the effect of ECM viscoelasticity on cells, and describe the potential use of viscoelastic biomaterials in regenerative medicine.
[Nature] |
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| Scientists review the use of microfluidics to study the physiology and pathophysiology of intact live tissues at sub-millimeter scales.
[Microsystems & Nanoengineering] |
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| Cytovia Therapeutics, has announced the filing of a provisional patent application with the US Patent & Trademark Office for the differentiation of natural killer (NK) cells from iPSCs. The NYSCF Research Institute is a pioneer and acknowledged leader in stem cell technology, having developed the premier automated robotic platform for reprogramming skin or blood into iPSCs and differentiating them into disease-relevant cell types.
[Cytovia Therapeutics, Inc. (GlobeNewswire, Inc.)] |
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| July 8 – 10, 2021
Boston, Massachusetts, United States |
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| | University Medical Centre Groningen (UMCG) – Groningen, Netherlands |
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| | Pennsylvania State University – Philadelphia, Pennsylvania, United States |
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| | Icahn School of Medicine, Mount Sinai – New York City, New York, United States |
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| | Wayne State University – Detroit, Michigan, United States |
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| | Institut Mondor de Recherche Biomédicale (IMRB) – Creteil, France |
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Cancer Stem Cell News
Cell Therapy News
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ESC & iPSC News
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Hematopoiesis News
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Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
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