Organoid News Volume 1.08 | Sep 3 2020

May 12, 2022

ON 1.08 | 3 Sept 2020

Vol. 1.08 – 3 September, 2020

TOP STORY

Single
Cell Transcriptomics Identifies a Signaling Network Coordinating Endoderm and Mesoderm Diversification During Foregut Organogenesis

Scientists validated key predictions with mouse genetics showing that differential hedgehog signaling from the epithelium patterns the splanchnic mesoderm into gut tube mesenchyme versus mesenchyme of the liver.
[Nature Communications]

Full Article

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PUBLICATIONSRanked by the impact factor of the journal

Bidirectional
Wnt Signaling between Endoderm and Mesoderm Confers Tracheal Identity in Mouse and Human Cells

Investigators showed that canonical Wnt signaling in mesoderm was critical to confer trachea mesenchymal identity in human and mouse.
[Nature Communications]

Full Article

Primate-Restricted
KRAB Zinc Finger Proteins and Target Retrotransposons Control Gene Expression in Human Neurons

Expressed in specific regions of the human developing and adult brain, ZNF417/587 kept controlling transposable element-embedded regulatory sequences in embryonic stem cells-derived neurons and brain organoids.
[Science Advances]

Full Article Press Release

SARS-CoV-2 Targets Neurons of 3D Human Brain Organoids

Scientists showed that a Düsseldorf isolate of SARS‐CoV‐2 entered 3D human brain organoids within two days of exposure. They identified that SARS‐CoV‐2 preferably targeted neurons of brain organoids.
[EMBO Journal]

Abstract

A
Biosensor for the Mitotic Kinase MPS1 Reveals Spatiotemporal Activity Dynamics and Regulation

Investigators showed deregulated MPS1 signaling dynamics in colorectal cancer cell lines and tumor organoids with diverse genomic instability phenotypes.
[Current Biology]

Full Article

Pleiotropic
Mechanisms Drive Endocrine Resistance in the Three-Dimensional Bone Microenvironment

Scientists cultured hormone receptor-positive breast cancer and prostate cancer spheroids and patient-derived organoids in 3D extracellular matrices alone or together with bone marrow stromal cells.
[Cancer Research]

Full Article

miR-183/96/182
Cluster Is an Important Morphogenetic Factor Targeting PAX6 Expression in Differentiating Human Retinal Organoids

Researchers used retinal organoids differentiated from human pluripotent stem cells as a model to closely investigate the role of a sensory organ‐specific and evolutionary conserved miR‐183/96/182 cluster.
[Stem Cells]

Abstract

Tumor
Resident Stromal Cells Promote Breast Cancer Invasion through Regulation of the Basal Phenotype

The authors developed a novel co-culture model of tumor organoids with autologous stromal cells. Co-culture significantly increased KRT14 expression and invasion of organoids from both luminal and basal murine breast cancer models.
[Molecular Cancer Research]

Abstract

Towards
Personalized Induction Therapy for Esophageal Adenocarcinoma: Organoids Derived from Endoscopic Biopsy Recapitulate the Pre-Treatment Tumor

Investigators developed a protocol to establish esophageal adenocarcinoma organoids from endoscopic biopsies of naïve esophageal adenocarcinomas.
[Scientific Reports]

Full Article

Evaluation
of Transplantation Sites for Human Intestinal Organoids

ESCs were differentiated into human intestinal organoids (HIOs) and HIOs from the same batch were transplanted on the same day into either the renal subcapsular space or mesentery. Ten weeks were allowed for engraftment and differentiation, at which time they were harvested and assessed.
[PLoS One]

Full Article

Immunofluorescence image of adult stem cell-derived intestinal organoids.

REVIEWS

Regen
Med Therapeutic Opportunities for Fighting COVID-19

Scientists evaluate some of the promising regenerative medicine‐based therapies for treating COVID‐19 and present some of the collective technologies and resources that the scientific community currently has available to confront this pandemic.
[Stem Cells Translational Medicine]

Full Article

Generation
of Insulin-Secreting Organoids: A Step Toward Engineering and Transplanting the Bioartificial Pancreas

The authors present approaches to generate islet cell organoids and discuss how these strategies can be applied to the generation of a bioartificial pancreas for the treatment of type 1 diabetes.
[Transplant International]

Abstract

3D In Vitro
Corneal Models: A Review of Current Technologies

Three major technologies are highlighted: organotypic cultures, organoids and 3D bioprinting. Also, several combinations of organotypic cultures, such as the epithelium and stroma or endothelium and neural cultures are discussed.
[Experimental Eye Research]

Abstract

INDUSTRY AND POLICY NEWS

Axol
Bioscience Appoints Liam Taylor as Chief Executive Officer

Axol Bioscience specialize in the use of stem cell technology to manufacture disease relevant cell based assay systems to the drug discovery industry. They have announced the appointment of Liam Taylor as CEO. Liam will guide the growth of the company, and will focus on maximizing the potential of the team, and its iPSC technologies, products and services.
[Axol Bioscience Ltd.]

Press Release

FEATURED EVENT

Single
Cell Transcriptomics Identifies a Signaling Network Coordinating Endoderm and Mesoderm Diversification During Foregut Organogenesis

Bidirectional
Wnt Signaling between Endoderm and Mesoderm Confers Tracheal Identity in Mouse and Human Cells

Primate-Restricted
KRAB Zinc Finger Proteins and Target Retrotransposons Control Gene Expression in Human Neurons

SARS-CoV-2 Targets Neurons of 3D Human Brain Organoids

A
Biosensor for the Mitotic Kinase MPS1 Reveals Spatiotemporal Activity Dynamics and Regulation

Pleiotropic
Mechanisms Drive Endocrine Resistance in the Three-Dimensional Bone Microenvironment

miR-183/96/182
Cluster Is an Important Morphogenetic Factor Targeting PAX6 Expression in Differentiating Human Retinal Organoids

Tumor
Resident Stromal Cells Promote Breast Cancer Invasion through Regulation of the Basal Phenotype

Towards
Personalized Induction Therapy for Esophageal Adenocarcinoma: Organoids Derived from Endoscopic Biopsy Recapitulate the Pre-Treatment Tumor

Evaluation
of Transplantation Sites for Human Intestinal Organoids

Regen
Med Therapeutic Opportunities for Fighting COVID-19

Generation
of Insulin-Secreting Organoids: A Step Toward Engineering and Transplanting the Bioartificial Pancreas

3D In Vitro
Corneal Models: A Review of Current Technologies

Axol
Bioscience Appoints Liam Taylor as Chief Executive Officer

Building
Brain Organoids and Assembloids

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Researcher – Organ on a Chip/Microfluidics and Toxicology

Postdoctoral Scholar – Biomedical Engineering in Regenerative Medicine

Postdoctoral Position – Lung Regeneration

Faculty
Position – Reproductive Origins of Health and Disease

Research Scientist – Breast Cancer and Organoid Cultures

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