Organoid News Volume 1.09 | Sep 10 2020

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    Justin.choi
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    ON 1.09 | 10 sept 2020


    Organoid News by STEMCELL Technologies
    Vol. 1.09 – 10 September, 2020
    TOP STORY

    Adaptable Hemodynamic Endothelial Cells for Organogenesis and Tumorigenesis

    Researchers demonstrated that ‘reset’ vascular endothelial cells established an adaptive vascular niche that differentially adjusted and conformed to organoids and tumoroids in a tissue-specific manner.
    [Nature]

    Full Article

    Grow Functional Airway Organoids with PneumaCult™
    PUBLICATIONSRanked by the impact factor of the journal

    ILC1 Drive Intestinal Epithelial and Matrix Remodelling

    Investigators developed gut organoid cocultures with type-1 innate lymphoid cells (ILC1) to dissect the impact of their accumulation in inflamed intestines.
    [Nature Materials]

    Abstract

    Engineering
    Transplantable Jejunal Mucosal Grafts Using Patient-Derived Organoids from Children with Intestinal Failure

    Researchers construct autologous jejunal mucosal grafts using biomaterials from pediatric patients and show that patient-derived organoids can be expanded efficiently in vitro.
    [Nature Medicine]

    Full ArticlePress Release

    Organoids
    Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells

    Scientists developed organoid systems from primary mouse and human induced pluripotent stem cell-derived lung epithelial cells to model early-stage lung adenocarcinoma.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    In Vitro
    Generation of Functional Murine Heart Organoids via FGF4 and Extracellular Matrix

    Investigators developed a method to generate heart organoids from mouse embryonic stem cell-derived embryoid bodies.
    [Nature Communications]

    Full Article

    Establishment
    and Differentiation of Long-Term Trophoblast Organoid Cultures from the Human Placenta

    Scientists describe a protocol to isolate trophoblast from first-trimester human placentas that can be grown long term in a three-dimensional organoid culture system.
    [Nature Protocols]

    Full Article

    YAP
    and AP-1 Cooperate to Initiate Pancreatic Cancer Development from Ductal Cells in Mice

    The authors clarify the unique consequences of YAP/TAZ activation in the ductal cell population of the pancreas by generating mice with pancreatic duct cell-specific, inducible knockouts of Lats1 and Lats2, the main kinases upstream of YAP/TAZ.
    [Cancer Research]

    Abstract

    Modeling
    Tumor Development and Metastasis Using Paired Organoids Derived from Patients with Colorectal Cancer Liver Metastases

    Researchers generated paired organoids derived from primary tumors and matched liver metastases in the same colorectal cancer patients.
    [Journal of Hematology & Oncology]

    Full Article

    The
    Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice

    Compromised gustatory sensing, achieved by Gnat3 ablation, enhanced the CXCL1/2 – CXCR2 axis to alter the myeloid-derived suppressor cell population and promoted the progression of metastatic pancreatic ductal adenocarcinoma.
    [Cellular and Molecular Gastroenterology and Hepatology]

    Abstract
    Full Article

    Human Cerebral Organoids Reveal Early Spatiotemporal Dynamics and Pharmacological Responses of UBE3A

    Human cerebral organoids revealed a change from weak to strong UBE3A in neuronal nuclei within three weeks of culture. Angelman syndrome human induced pluripotent stem cell-derived organoids also exhibited early silencing of paternal UBE3A, with topoisomerase inhibitors partially rescuing UBE3A levels and calcium transient phenotypes.
    [Stem Cell Reports]

    Full Article
    Graphical Abstract

    Differentiated
    Cancer Cell-Originated Lactate Promotes the Self-Renewal of Cancer Stem Cells in Patient-Derived Colorectal Cancer Organoids

    Organoid models were employed to show that cancer stem cells (CSCs) and non-CSCs in colorectal cancer were characterized by distinct metabolic phenotypes.
    [Cancer Letters]

    Abstract

    3D Co-Culture of Cancer-Associated Fibroblast with Oral Cancer Organoids

    The three-dimensional organoid model was employed to investigate whether co-culture with paralleled cancer-associated fibroblasts promoted stem-like properties of oral squamous cell carcinoma.
    [Journal of Dental Research]

    Abstract

    Webinar on brain-region-specific organoids and assembloids by Dr. Sergiu Pasca
    REVIEWS

    Patient-Derived
    Midbrain Organoids to Explore the Molecular Basis of Parkinson’s Disease

    The authors review existing protocols to generate human midbrain organoids, how they have been used so far to model Parkinson’s disease. address challenges inherent to organoid cultures, and discuss applicable strategies to dissect the molecular pathophysiology of the disease.
    [Frontiers in Neurology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Recce Pharmaceuticals Announces Positive & Concentration-Dependent Efficacy of RECCE® Compounds against COVID-19 in International Study

    Recce Pharmaceuticals Ltd provided an update on their international SARS-CoV-2 in vitro (organoid) studies undertaken by Path BioAnalytics Inc. and The University of Tennessee Health Science Center.
    [Recce Pharmaceuticals Ltd (GlobeNewswire, Inc.)]

    Press Release

    FEATURED EVENT

    Channels
    in Context: Structure and Function of Ion Channels in Macromolecular Complexes and Native Cells

    Sep 7 – 11, 2022
    Woods Hole, Massachusetts, United States


    > See All Events

    JOB OPPORTUNITIES

    Research
    Positions – Organs on a Chip

    Terasaki Research Institute – Los Angeles, California, United States


    Postdoctoral Scholar – Biomedical Engineering in Regenerative Medicine

    Pennsylvania State University – Philadelphia, Pennsylvania, United States

    Faculty
    Position – Reproductive Origins of Health and Disease

    Wayne State University – Detroit, Michigan, United States

    Research Scientist – Breast Cancer and Organoid Cultures

    Icahn School of Medicine, Mount Sinai – New York City, New York, United States

    Postdoctoral Position – Lung Regeneration

    Institut Mondor de Recherche Biomédicale (IMRB) – Creteil, France

    > See All Jobs

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