 | | Vol. 1.12 – 1 October, 2020 |
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| Using electrophysiology and live imaging, the authors identified defects in spontaneous neuronal activity and calcium signaling in both organoid- and 2D-derived cortical neurons.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Single-cell transcriptome analysis identified brain-derived neurotrophic factor as a STAT3 target gene with newly accessible chromatin in a unique population of regenerating AT2 cells.
[Nature Cell Biology] |
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| The authors established a three‐dimensional murine bronchioalveolar lung organoid model that allows clonal expansion and self‐organization of FACS‐sorted bronchioalveolar stem cells upon co‐culture with lung‐resident mesenchymal cells.
[EMBO Journal] |
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| The orthotopic transplantation of patient‐derived or patient‐derived tumor xenograft (PDX)‐derived organoids was demonstrated into submandibular glands of NSG mice and their histology was evaluated. PDX‐derived organoid cells were evaluated for the presence of MYB‐mediated fusion genes and proceeded for in vitro drug sensitivity assay.
[International Journal of Cancer] |
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| Investigators profiled the neuroelectrical activities of cerebral organoids over the span of five months with a multi-electrode array platform and observed the emergence and maturation of several electrophysiologic properties, including rapid firing rates and network bursting events.
[Stem Cell Reports] |
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| Scientists generated BAX/BAK double knockout human-induced pluripotent stem cells (hiPSCs), hiPSC-derived neural progenitor cells, neural rosettes, and cerebral organoids to uncover the effects of BAX and BAK deletion in an in vitro model of early human brain development.
[Cell Death & Disease] |
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| Hemin catalyzed the formation of reactive oxygen species (ROS) and induced oxidative DNA damage as well as DNA strand breaks in both human colonic epithelial and colorectal cancer cells. In contrast, inorganic iron hardly affected ROS levels and only slightly increased DNA damage. Hemin, but not inorganic iron, caused cell death and reduced cell viability.
[Cell Death & Disease] |
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| Upon adipogenesis, the effects on lipid staining, the mRNA expression of adipogenesis-related genes and the extracellular matrx, and the size and physical property of 3D organoids were compared between groups that had been treated with EP2 agonists and PGF2α.
[Scientific Reports] |
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| Fibroblast-conditioned media (fCM)-mediated response seemed to be spatially-dependent as cardiomyocyte organoids treated with fCM had increased expression of connexin 40 and NAV1.5 primarily on its outer surface.
[Scientific Reports] |
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| Scientists examined the potential use of limbal organoids as a source of transplantable limbal stem cells. After treating tissue with collagenase, limbal cells were seeded onto Matrigel and cultivated using limbal phenotype maintenance medium.
[Stem Cell Research] |
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| The authors focus on the latest approaches to study neuroscience related topics with organoids, such as the use of assembloids, CRISPR technology, patch-clamp and optogenetics techniques and discuss how modern 3-dimensional biomaterials, miniaturized bioreactors and microfluidic chips can help to overcome the disadvantages of their use.
[Neuroscientist] |
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| Qihan Biotech has announced the expansion of its Scientific Advisory Board to include a total of 12 world-renowned experts in synthetic biology, regenerative medicine, transplantation immunology and cell therapy, as well as the formation of several Scientific Advisory Committees.
[Qihan Biotech (Businesswire, Inc.)] |
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| November 11 – November 13
Virtual |
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| | The University of Georgia – Athens, Georgia, United States |
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| | University Hospital of Muenster – Münster, Germany |
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| | Terasaki Research Institute – Los Angeles, California, United States |
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| | Pennsylvania State University – Philadelphia, Pennsylvania, United States |
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| | Wellcome Sanger Institute – Cambridge, England, United Kingdom |
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| | Vitalant Research Institute – San Francisco, California, United States |
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