| Vol. 1.20 – 26 November, 2020 |
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| Researchers generated long-term feeder-free, chemically defined culture of distal lung progenitors as organoids derived from single adult human alveolar epithelial type II or KRT5+ basal cells. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists applied extrusion-based 3D cellular bioprinting to deliver rapid and high-throughput generation of kidney organoids with highly reproducible cell number and viability. [Nature Materials] |
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| The authors demonstrated that deficiency in Fam3D was associated with impaired integrity of colonic mucosa, increased epithelial hyper-proliferation, reduced anti-microbial peptide production and increased sensitivity to chemically induced colitis associated with high incidence of cancer. [Nature Communications] |
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| Investigators showed that the miRNA cargo of extracellular vesicles (EVs) from pancreatic ductal adenocarcinoma organoids largely differs among patients. However, they detected a common set of EV miRNAs that were present in matched organoids and blood plasma samples of individual patients. [Cellular and Molecular Life Sciences] |
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| Researchers mimicked the ablation of S1PR2 in normal mucosa by treating S1PR2+/+ organoids with JTE013 and characterized intestinal epithelial stem cells isolated from S1PR2-/-Lgr5-EGFP- mice. [Journal of Experimental & Clinical Cancer Research] |
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| Scientists performed single‐cell RNA sequencing of fibroblast‐dependent alveolar organoids, including human induced pluripotent stem cell‐derived epithelial cells and fetal lung fibroblasts, and identified hiPSC‐derived AT1 cells. [Stem Cells] |
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| To derive definitive hematopoietic stem/precursor cells from human embryonic stem cells, the authors differentiated mesodermally specified embryoid bodies on gelatin-coated plates in serum/feeder-free conditions. [Stem Cell Research & Therapy] |
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| TGFβ2 significantly increased the TEER values in 2D cultures, and the ECM expression indicated that the 3D organoids assumed a more densely packed shape. [Scientific Reports] |
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| Investigators aimed to establish a new method to generate brain organoids efficiently in a mouse model. They applied the in vivo teratoma formation method as a new approach to generate brain organoids. [Stem Cell Research] |
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| Scientists describe the peptidomic analysis of organoid lysates, FACS-purified cell populations, and 2D culture secretions by liquid chromatography mass spectrometry. [STAR Protocols] |
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| The authors summarize current methodologies for organoid/spheroid formation and a potential for 3D hepatic cell cultures as novel in vitro models of cholangiopathies. [Hepatology] |
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| Scientists discuss how Wnt and YAP signaling pathways control the intestinal repair response and the transitioning of cell states, in comparison with the process of intestinal development. [Cell Death & Differentiation] |
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| Investigators review the current situation of organoids and organ chips in ophthalmology and discuss how they can be leveraged for translational applications. [Ocular Surface] |
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| Caribou Biosciences, Inc. announced the execution of an exclusive license agreement with Memorial Sloan Kettering Cancer Center under which Caribou has rights to fully human anti-CD371 scFvs and intellectual property related thereto in the field of allogeneic CD371-targeted cell therapies including CAR-T, CAR-NK, or iPSC-derived cell products. [Caribou Biosciences, Inc.] |
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| June 23 – June 26, 2021 Hamburg, Germany |
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| Genentech, Inc. – South San Francisco, California, United States |
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| Ncardia – Share Gosselies, Belgium |
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| New York Blood Center – New York, New York, United States |
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| Columbia University Medical Center – New York, New York, United States |
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| Columbia University Medical Center – New York, New York, United States |
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