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| Vol. 1.20 – 26 November, 2020
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Researchers generated long-term feeder-free, chemically defined culture of distal lung progenitors as organoids derived from single adult human alveolar epithelial type II or KRT5+ basal cells.
[Nature]
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| PUBLICATIONSRanked by the impact factor of the journal
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Scientists applied extrusion-based 3D cellular bioprinting to deliver rapid and high-throughput generation of kidney organoids with highly reproducible cell number and viability.
[Nature Materials]
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The authors demonstrated that deficiency in Fam3D was associated with impaired integrity of colonic mucosa, increased epithelial hyper-proliferation, reduced anti-microbial peptide production and increased sensitivity to chemically induced colitis associated with high incidence of cancer.
[Nature Communications]
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Investigators showed that the miRNA cargo of extracellular vesicles (EVs) from pancreatic ductal adenocarcinoma organoids largely differs among patients. However, they detected a common set of EV miRNAs that were present in matched organoids and blood plasma samples of individual patients.
[Cellular and Molecular Life Sciences]
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Researchers mimicked the ablation of S1PR2 in normal mucosa by treating S1PR2+/+ organoids with JTE013 and characterized intestinal epithelial stem cells isolated from S1PR2-/-Lgr5-EGFP- mice.
[Journal of Experimental & Clinical Cancer Research]
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Scientists performed single‐cell RNA sequencing of fibroblast‐dependent alveolar organoids, including human induced pluripotent stem cell‐derived epithelial cells and fetal lung fibroblasts, and identified hiPSC‐derived AT1 cells.
[Stem Cells]
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To derive definitive hematopoietic stem/precursor cells from human embryonic stem cells, the authors differentiated mesodermally specified embryoid bodies on gelatin-coated plates in serum/feeder-free conditions.
[Stem Cell Research & Therapy]
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TGFβ2 significantly increased the TEER values in 2D cultures, and the ECM expression indicated that the 3D organoids assumed a more densely packed shape.
[Scientific Reports]
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Investigators aimed to establish a new method to generate brain organoids efficiently in a mouse model. They applied the in vivo teratoma formation method as a new approach to generate brain organoids.
[Stem Cell Research]
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Scientists describe the peptidomic analysis of organoid lysates, FACS-purified cell populations, and 2D culture secretions by liquid chromatography mass spectrometry.
[STAR Protocols]
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The authors summarize current methodologies for organoid/spheroid formation and a potential for 3D hepatic cell cultures as novel in vitro models of cholangiopathies.
[Hepatology]
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Scientists discuss how Wnt and YAP signaling pathways control the intestinal repair response and the transitioning of cell states, in comparison with the process of intestinal development.
[Cell Death & Differentiation]
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Investigators review the current situation of organoids and organ chips in ophthalmology and discuss how they can be leveraged for translational applications.
[Ocular Surface]
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Caribou Biosciences, Inc. announced the execution of an exclusive license agreement with Memorial Sloan Kettering Cancer Center under which Caribou has rights to fully human anti-CD371 scFvs and intellectual property related thereto in the field of allogeneic CD371-targeted cell therapies including CAR-T, CAR-NK, or iPSC-derived cell products.
[Caribou Biosciences, Inc.]
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June 23 – June 26, 2021
Hamburg, Germany
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| Genentech, Inc. – South San Francisco, California, United States
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| Ncardia – Share Gosselies, Belgium
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| New York Blood Center – New York, New York, United States
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| Columbia University Medical Center – New York, New York, United States
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| Columbia University Medical Center – New York, New York, United States
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
