Organoid News Volume 1.20 | Nov 26 2020

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    ON 1.20 | Nov 26 2020


    Organoid News by STEMCELL Technologies
    Vol. 1.20 – 26 November, 2020
    TOP STORY

    Progenitor Identification and SARS-CoV-2 Infection in Human Distal Lung Organoids

    Researchers generated long-term feeder-free, chemically defined culture of distal lung progenitors as organoids derived from single adult human alveolar epithelial type II or KRT5+ basal cells.
    [Nature]

    Abstract

    Virtual Conference Exhibition: Organoids
    PUBLICATIONSRanked by the impact factor of the journal

    Cellular
    Extrusion Bioprinting Improves Kidney Organoid Reproducibility and Conformation

    Scientists applied extrusion-based 3D cellular bioprinting to deliver rapid and high-throughput generation of kidney organoids with highly reproducible cell number and viability.
    [Nature Materials]

    Abstract

    FAM3D
    is Essential for Colon Homeostasis and Host Defense against Inflammation Associated Carcinogenesis

    The authors demonstrated that deficiency in Fam3D was associated with impaired integrity of colonic mucosa, increased epithelial hyper-proliferation, reduced anti-microbial peptide production and increased sensitivity to chemically induced colitis associated with high incidence of cancer.
    [Nature Communications]

    Full Article

    Shared
    Extracellular Vesicle miRNA Profiles of Matched Ductal Pancreatic Adenocarcinoma Organoids and Blood Plasma Samples Show the Power of Organoid Technology

    Investigators showed that the miRNA cargo of extracellular vesicles (EVs) from pancreatic ductal adenocarcinoma organoids largely differs among patients. However, they detected a common set of EV miRNAs that were present in matched organoids and blood plasma samples of individual patients.
    [Cellular and Molecular Life Sciences]

    Full Article

    Unveiling
    Role of Sphingosine-1-Phosphate Receptor 2 as a Brake of Epithelial Stem Cell Proliferation and a Tumor Suppressor in Colorectal Cancer

    Researchers mimicked the ablation of S1PR2 in normal mucosa by treating S1PR2+/+ organoids with JTE013 and characterized intestinal epithelial stem cells isolated from S1PR2-/-Lgr5-EGFP- mice.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Directed
    Induction of Alveolar Type I Cells Derived from Pluripotent Stem Cells via Wnt Signaling Inhibition

    Scientists performed single‐cell RNA sequencing of fibroblast‐dependent alveolar organoids, including human induced pluripotent stem cell‐derived epithelial cells and fetal lung fibroblasts, and identified hiPSC‐derived AT1 cells.
    [Stem Cells]

    Full Article

    Definitive
    Hematopoietic Stem/Progenitor Cells from Human Embryonic Stem Cells through Serum/Feeder-Free Organoid-Induced Differentiation

    To derive definitive hematopoietic stem/precursor cells from human embryonic stem cells, the authors differentiated mesodermally specified embryoid bodies on gelatin-coated plates in serum/feeder-free conditions.
    [Stem Cell Research & Therapy]

    Full Article

    ROCK
    Inhibitors Beneficially Alter the Spatial Configuration of TGFβ2-Treated 3D Organoids from a Human Trabecular Meshwork (HTM)

    TGFβ2 significantly increased the TEER values in 2D cultures, and the ECM expression indicated that the 3D organoids assumed a more densely packed shape.
    [Scientific Reports]

    Full Article

    Generation
    of Brain Organoids from Mouse ESCs via Teratoma Formation

    Investigators aimed to establish a new method to generate brain organoids efficiently in a mouse model. They applied the in vivo teratoma formation method as a new approach to generate brain organoids.
    [Stem Cell Research]

    Full ArticleGraphical Abstract

    Organoid Sample Preparation and Extraction for LC-MS Peptidomics

    Scientists describe the peptidomic analysis of organoid lysates, FACS-purified cell populations, and 2D culture secretions by liquid chromatography mass spectrometry.
    [STAR Protocols]

    Full ArticleGraphical Abstract

    Immunofluorescence image of adult stem cell-derived intestinal organoids.
    REVIEWS

    Organoids
    and Spheroids As Novel Models for Studying Cholestatic Liver Injury and Cholangiocarcinoma

    The authors summarize current methodologies for organoid/spheroid formation and a potential for 3D hepatic cell cultures as novel in vitro models of cholangiopathies.
    [Hepatology]

    Abstract

    Organoid-Based Modeling of Intestinal Development, Regeneration, and Repair

    Scientists discuss how Wnt and YAP signaling pathways control the intestinal repair response and the transitioning of cell states, in comparison with the process of intestinal development.
    [Cell Death & Differentiation]

    Full Article

    Organoids and Organ Chips in Ophthalmology

    Investigators review the current situation of organoids and organ chips in ophthalmology and discuss how they can be leveraged for translational applications.
    [Ocular Surface]

    AbstractGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Caribou
    Biosciences Announces Licensing Agreement for scFvs Targeting CD371 to Enable Development of Allogeneic Cell Therapies

    Caribou Biosciences, Inc. announced the execution of an exclusive license agreement with Memorial Sloan Kettering Cancer Center under which Caribou has rights to fully human anti-CD371 scFvs and intellectual property related thereto in the field of allogeneic CD371-targeted cell therapies including CAR-T, CAR-NK, or iPSC-derived cell products.
    [Caribou Biosciences, Inc.]

    Press Release

    FEATURED EVENT

    ISSCR 2021 Annual Meeting

    June 23 – June 26, 2021
    Hamburg, Germany


    > See All Events

    JOB OPPORTUNITIES

    Senior
    Scientific Researcher – In Vitro Human Brain Modeling

    Genentech, Inc. – South San Francisco, California, United States

    Senior
    Scientist – Stem Cell Biology

    Ncardia – Share Gosselies, Belgium

    Research
    Fellow – Stem Cell Biology & Engineering

    New York Blood Center – New York, New York, United States

    Postdoctoral
    Fellow – Skin Organoids

    Columbia University Medical Center – New York, New York, United States

    Postdoctoral
    Research Scientist – Stem Cell and Tissue Engineering

    Columbia University Medical Center – New York, New York, United States

    > See All Jobs

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