 | | Vol. 1.21 – 3 December, 2020 |
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| Researchers developed a method to convert human pluripotent stem cells into region-specific brain organoids that resemble the developing human striatum and include electrically active medium spiny neurons.
[Nature Biotechnology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated orthogonal programming by including oligodendrocyte-inducible hPSCs with unmodified hPSCs to generate cerebral organoids, which expedited in situ myelination.
[Nature Biotechnology] |
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| Investigators established culture conditions that facilitated long-term expansion of human fetal hepatocytes as organoids.
[Nature Protocols] |
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| FLASH utilizes non-degradative epitope recovery and membrane solubilization to enable the detection of a multitude of membranous, cytoplasmic and nuclear antigens in whole mouse organs and embryos, human biopsies, organoids and Drosophila.
[Nature Protocols] |
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| Researchers identified that ion flow through gap junctions promoted peripheral cell swelling in loaded breast cancer model.
[Nature Communications] |
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| Hepatic progenitor cells either derived in microfluidics or exposed to exogenous ECM stimuli showed a significantly higher potential of forming hepatic organoids that could be rapidly expanded for several passages and further differentiated into functional hepatocytes.
[Cell Reports] |
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| Scientists performed a proteomic kinome analysis in ESR1 Y537S mutant cells to identify hyperactivated kinases in ESR1 mutant cells. They validated Recepteur d’Origine Nantais (RON) and PI3K hyperactivity through phospho-immunoblot analysis, organoid growth assays, and in an in vivo patient-derived xenograft metastatic model.
[British Journal of Cancer] |
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| Using 3D super resolution microscopy, ZIKV infection was shown to induce the formation of dense tubular matrices associated with viral replication in the central endoplasmic reticulum.
[Scientific Reports] |
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| Scientists present the feasibility of a multimodal approach, combining electrophysiology and broadband Vis–NIR spectroscopy, to monitor neurodevelopment in brain organoid models that could complement traditional drug design approaches to test clinically meaningful hypotheses.
[Scientific Reports] |
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| Both glioblastoma stem cells, grown in classical 2D culture and in 3D-tumor organoids, formed functional tunneling nanotubes which allowed mitochondria transfer.
[Biochemical Journal] |
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| Investigators review different adult stem cell derived gastric organoid model systems and focus on their establishment, phenotypic and genotypic characterizations as well as their use in predicting therapy response.
[Cell Death & Differentiation] |
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| Researchers cover the latest research on damage-associated regenerative ISCs and epigenetic factors that determine intestinal stem cell (ISC) fate, as well as provide opinions on future studies that need to be undertaken to understand the repercussions of the emergence of these cells, their contribution to relapses in inflammatory bowel disease, and their potential use in therapeutics for chronic intestinal diseases.
[Frontiers in Cell and Developmental Biology] |
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| To mark the end of Diabetes Awareness Month, Sonia Sidhu, Member of Parliament for Brampton South, on behalf of the Honourable Patty Hajdu, Minister of Health, announced an investment of $6 million through the CIHR-JDRF Partnership to Defeat Diabetes for two Canadian research teams to accelerate the development of stem cell-based therapies for the treatment of type 1 diabetes.
[Juvenile Diabetes Research Foundation] |
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| June 10 – June 11, 2021
London, England, United Kingdom |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | Ncardia – Share Gosselies, Belgium |
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| | New York Blood Center – New York, New York, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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