 | | Vol. 2.07 – 25 February, 2021 |
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| Researchers generated a functional small intestinalized colon by replacing the native colonic epithelium with ileum-derived organoids.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using single-cell RNA sequencing, investigators showed that primary human cholangiocytes displayed transcriptional diversity that is lost in organoid culture.
[Science] |
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| Based on genome-wide analysis of the epigenetic clock and transcriptomics, as well as RNA editing, researchers observed that 3D human cortical organoids reached postnatal stages between 250 and 300 days, a timeline paralleling in vivo development.
[Nature Neuroscience] |
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| Specific variations in YTHDF1 expression were detected in YTHDF1-overexpressing, -knockout, and -knockdown human hepatocellular carcinoma (HCC) cells, HCC organoids, and HCC patient-derived xenograft murine models.
[Signal Transduction and Targeted Therapy] |
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| The authors describe an androgen-dependent prostate cancer patient-derived xenograft model from treatment-naïve, soft tissue metastasis.
[Nature Communications] |
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| The impact of endoplasmic reticulum stress induced by Thapsigargin on serine protease secretion was studied using either human intestinal cells lines or organoids.
[Journal of Crohn’s and Colitis] |
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| Researchers established and molecularly characterized CoCaB 1, an aggressive cisplatin-resistant muscle-invasive bladder cancer patient-derived xenograft and companion organoid system.
[Scientific Reports] |
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| Scientists used endometrial stromal, primary endometriotic stromal, epithelial endometriotic and co-culture spheroids to mimic the architecture of endometrium, and either collagen I or Matrigel to model ectopic locations.
[Scientific Reports] |
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| Investigators developed a novel electrochemical sensing approach capable of detecting dopamine, the main biomarker in Parkinson’s disease, within the highly complex cell culture matrix of human midbrain organoids in a non-invasive and label-free manner.
[Analyst] |
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| Researchers describe a chemically defined protocol for 3D culture and propagation of glioblastoma in 3D gliospheres, patient-derived organoids, mouse brain orthotopic xenografts, and downstream drug and immunofluorescence assays.
[STAR Protocols] |
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| The authors investigate cell surface and genetic engineering approaches, and discuss stem cell niche engineering based on the design of matrices that allow spatiotemporal control of organoid growth and shape-guided morphogenesis.
[Nature Reviews Materials] |
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| Century Therapeutics announced a significant expansion of its operational and laboratory space in Philadelphia, as well as progress on its manufacturing facility in Branchburg, NJ, paving the way for a strong technical foundation as the company scales up its in-house research and development capabilities.
[Century Therapeutics (PR Newswire, LLC)] |
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| March 29 – 30, 2021
Virtual |
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| | Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | Merck Sharp and Dohme Limited – London, England, United Kingdom |
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| | NCCR AntiResist – Basel, Switzerland |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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