 | | Vol. 2.11 – 25 March, 2021 |
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| Scientists developed a new platform to address the limitations by fusing human and chimpanzee induced pluripotent stem cells to generate a panel of tetraploid hybrid stem cells.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers used cerebral organoids derived from human, gorilla, and chimpanzee cells to study developmental mechanisms driving evolutionary brain expansion.
[Cell] |
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| Tumor organoids and 2D cell lines derived from cholangiocarcinoma lesions were addicted to fibroblast growth factor receptor 2 fusion protein (FF) signaling via Ras-Erk, regardless of FF identity or V565F mutation.
[Journal of Hepatology] |
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| Using single cell and single molecule approaches in mammary epithelial cells and primary organoid, researchers found that epithelial tissues responded to bacterial microbe associated molecular patterns.
[Nature Communications] |
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| 3D high-content screening of ~23,000 compounds using dual-reporter mesenchymal SW620 tumor organoids identified small molecule probes that modulate EMT, and a subset of probes that effectively induced MET.
[Oncogene] |
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| Tumor cells isolated from resected tumours were subjected to organoid cultures based on published protocols with modifications.
[European Journal of Cancer] |
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| Scientists demonstrated successful offspring production of ovarian organoids derived from spermatogonial stem cells by defined factors with chromatin reorganization.
[Journal of Advanced Research] |
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| Researchers investigated whether human placenta mesenchymal stem cell-derived exosomes exerted a protective effect in senescent cholangiocyte organoids.
[Stem Cell Research & Therapy] |
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| Investigators used an unguided/unpatterning differentiation method to generate six-month-old cerebral organoids from iPSC lines to assess the suitability of an in vitro system to measure APOE, β amyloid, and Tau phosphorylation levels.
[Stem Cell Reviews and Reports] |
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| The authors investigated whether stem cell-derived otic vesicles could autonomously generate inner ear organoids.
[Stem Cell Research] |
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| Scientists tested the novel capsids AAV9.GL and AAV9.NN for their tropism and transduction efficiency in hiPSC-derived human retinal organoids with all major neuronal and glial cell types in a laminated structure.
[Human Gene Therapy] |
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| Investigators evaluated the specificities of seven commercial UBE3A antibodies in two of the major experimental models used in UBE3A research, mouse and human pluripotent stem cell-derived neural cells and tissues.
[Scientific Reports] |
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| The authors studied the effect of PINK1 deficiency on adult neurogenesis of dopaminergic neurons in two complementary model systems
[Scientific Reports] |
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| The authors discuss general strategies to create vascularized organoids, including common source materials, and survey previous work using vascularized organoids to recreate specific organ functions and simulate tumor progression.
[Annual Review of Biomedical Engineering] |
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| Scientists summarize the efforts to accomplish vascularization and perfusion of brain organoids, and they discuss these attempts from a forward‐looking perspective.
[Stem Cells] |
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| Exacis Biotherapeutics Inc., announced several important steps in the preclinical development of its ExaNK™ engineered NK cell-therapy candidates.
[Exacis Biotherapeutics Inc. (PR Newswire LLC.)] |
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| Funded in part by a $424,000 gift establishing the Gail V. Coleman and Kenneth M. Bruntel Organoids for Personalized Therapy Grant, organoid analysis has been included in an upcoming clinical trial to determine if the organoid response to drugs in the lab can accurately predict which chemotherapy will be most effective for each patient.
[Lustgarten Foundation Pancreatic Cancer Foundation] |
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| April 19 – 23, 2021
Virtual |
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| | Nanyang Technological University – Singapore, Singapore |
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| | Gladstone Institute – San Francisco, California, United States |
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| | Helmholtz Association – Tübingen, Germany |
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| | AMOLF – Amsterdam, Netherlands |
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| | Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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