 | | Vol. 2.16 – 29 April, 2021 |
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| Scientists report induction of human pluripotent stem cells toward pancreatic ductal and acinar organoids that recapitulated properties of the neonatal exocrine pancreas.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers differentiated hPSCs into pancreatic duct-like organoids with morphological, transcriptional, proteomic, and functional characteristics of human pancreatic ducts, further maturing upon transplantation into mice.
[Cell Stem Cell] |
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| After hepatic differentiation, nonalcoholic steatohepatitis liver organoids exhibited reduced ability to dedifferentiate back to the biliary state, consistent with the known reduced regenerative ability of NASH livers.
[Hepatology] |
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| Scientists identified RAC1B as an important mediator of colorectal tumourigenesis and a potential target for enhancing the efficacy of EGFR inhibitor treatment.
[Nature Communications] |
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| iPSCs derived from individuals deficient in CDKL5 protein were used to generate neural cells. Proteomic and phosphoproteomic approaches revealed disruption of several pathways, including microtubule-based processes and cytoskeleton organization.
[Molecular Psychiatry] |
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| Researchers describe a protocol for measuring Young’s modulus of soft 2D surfaces and 3D hydrogels using atomic force microscopy (AFM) force spectroscopy. They provide instructions for preparing hydrogels with and without encapsulated live cells, and provide a method for mounting samples within the AFM.
[Nature Protocols] |
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| Scientists generated 5-hydroxymethylcytosine and transcriptome profiles encompassing several developmental time points of healthy forebrain organoids and organoids derived from several familial Alzheimer’s disease patients.
[Cell Reports] |
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| Investigators analyzed Lgr5-Cre; APCmin; HER2V777LTg mice by morphologic and gene expression assays on intestinal sections and organoids derived from the epithelium.
[Cellular and Molecular Gastroenterology and Hepatology] |
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| Scientists describe an approach to generate gastruloids that have a more complete antero-posterior development.
[Stem Cell Reports] |
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| Researchers showed that extracellular vesicles isolated from mouse and human intestinal organoids modulated inflammatory responses of various immune cells including mouse bone-marrow derived-macrophages, dendritic cells, microglia cells, and human monocytes.
[Mucosal Immunology] |
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| The authors showed that the nuclear aggregates of APP-CT50 fragments together with PML and FE65 were present in the aged human brain but not in cerebral organoids differentiated from iPS cells.
[Acta Neuropathologica Communications] |
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| The effects of prostaglandin F2α analogues (PGF2α-ags) on human orbital fibroblasts were characterized by lipid staining, comparison of the 3D organoid sizes of preadipocytes or adipocytes that had been treated with various concentrations of several PGF2α-ags, physical stiffness, and the mRNA expression of adipogenic related genes, extracellular matrix, tissue inhibitors of metalloproteinases and matrix metalloproteinases.
[Scientific Reports] |
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| Scientists introduce the current state of brain organoid differentiation strategies, summarize current progress and applications in the medical domain, and discuss the challenges and prospects of this promising technology.
[Journal of Biomedical Science] |
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| The authors examine recent studies that have defined changes in the epigenomic landscape during fetal brain development. They compare these studies with analogous data derived by in vitro differentiation of hPSCs into specific neuronal cell types or as 3D cerebral organoids.
[Neurochemistry International] |
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| CARISMA Therapeutics, Inc. announced it has established a multi-year scientific collaboration with Bruce Blazar, MD, Regents Professor of Pediatrics, Division of Blood and Marrow Transplantation and Cellular Therapy at the University of Minnesota to investigate and develop allogeneic macrophage therapies.
[CARISMA Therapeutics, Inc. (PR Newswire LLC)] |
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| June 14 – 18, 2021
Virtual |
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| | Stanford University – Stanford, California, United States |
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| | Oregon Health & Science University – Portland, Oregon, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | Nanyang Technological University – Singapore, Singapore |
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| | Helmholtz Association – Tübingen, Germany |
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