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| The authors deployed high-throughput screening strategies to identify a small-molecule cocktail that improves viability of human PSCs and their differentiated progeny.
[Nature Methods] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported the generation of arcuate organoids from human iPSCs to model the development of the human hypothalamic arcuate nucleus.
[Cell Stem Cell] |
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| The authors examined processes governing the size of stem cell zones. They improved the viability and homogeneity of intestinal organoid cultures to enable long-term time-lapse imaging of multiple organoids in parallel.
[Cell Stem Cell] |
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| Scientists performed histological assays and unbiased single-cell RNA sequencing analysis on cerebral organoids derived from four euploid cell lines and from iPSCs to explore cell type-specific abnormalities associated with Down syndrome during early brain development.
[Journal of Clinical Investigation] |
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| Investigators developed human iPSC-derived myelinating organoids and quantitative tools to study myelination from oligodendrogenesis through to compact myelin formation and myelinated axon organization.
[Developmental Cell] |
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| Scientists used diagnostic leukapheresis to enrich circulating tumor cells from patients with metastatic prostate cancer and explored whether organoids provide a platform for ex vivo treatment modeling.
[European Journal of Cancer] |
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| Researchers used iPSC technology and established a 3D, organoid-like differentiation system maintaining the structural cellular integrity to evaluate the effect of cytokines on embryonic hematopoietic development.
[Haematologica] |
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| The authors investigated the value of the response in pS6 for predicting the efficacy of trametinib, a MEK inhibitor, in patients with RAS/BRAF mutant colorectal cancer (CRC) using patient-derived CRC organoids.
[Laboratory Investigation] |
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| Scientists demonstrated that while low dose of GSK3β inhibitor CHIR 99021 increases organoid size, higher dose actually reduced organoid size; with the highest dose arresting organoid growth.
[PLoS One] |
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| The authors describe how cholangiocyte organoids could be used in the context of cholangiopathies and show bile duct repair by successfully transplanting these organoids in the human liver.
[Hepatology] |
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| Advances in gene-editing technologies, particularly CRISPR-mediated techniques, offer tremendous potential in facilitating organoid research, including the study of development, disease modeling, and personalized medicine.
[Trends in Biotechnology] |
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| New models of posterior embryo development identify neuromesodermal progenitors as a major bifurcation point in generating the spinal cord and somites and is leading to production of cell types with the full range of axial identities critical for repair of trunk and spine disorders. This is coupled with organoid technologies including assembloids, circuitoids, and gastruloids.
[Frontiers in Cellular Neuroscience] |
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| For the first time in history, scientists will be able to send human organoids for advanced cancer studies into space- and they are sending them there onboard China’s future space station.
[CTGN] |
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| A research team from the Duke Center for Genomic and Computational Biology have teamed up with scientists at UNC-Chapel Hill and Flora Vaccarino at Yale University to narrow down areas of the genome previously marked relevant to schizophrenia risk.
[Mirage News] |
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| | Elsevier – Cambridge, Massachusetts, United States |
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| | Ncardia- Leiden, The Netherlands |
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| | Stanford University – Stanford, California, United States |
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| | Oregon Health & Science University – Portland, Oregon, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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