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| Finite element analysis served as a design tool to guide selection of geometries and material parameters for shape-matching 3D architectures tailored to organoids of interest.
[Advanced Materials] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed how in vitro gut-chip models could be used to construct mechanistic models of strain activity and recapitulate the behavior of the engineered strain in a non-human primate model.
[Nature Communications] |
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| Researchers used a human intestinal organoid model to define host transcriptional responses to S. Typhimurium infection, also determining host pathways dependent on Salmonella pathogenicity island- 1- and -2-encoded type 3 secretion systems
[mBio] |
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| Scientists generated 2D and 3D in vitro human Fragile X Syndrome model systems based on isogenic fragile X mental retardation protein knock-out mutant and wild-type human hiPSC lines.
[Cell Death & Disease] |
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| Investigators implemented novel patient-derived organoid and patient-derived xenografts strategies for high-throughput drug screening.
[JCI Insight] |
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| Intestinal organoids derived from mouse small intestine were treated with vitamin D3, and the effects on intestinal stemness and differentiation were evaluated using real-time PCR and immunofluorescence staining of the distinct lineage markers.
[Stem Cell Research & Therapy] |
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| Researchers demonstrated that equilibration of mouse islets with small molecules in aqueous solutions could be accelerated from greater than 24 to 6 hours by increasing incubation temperature to 37°C.
[Scientific Reports] |
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| Investigators implemented novel patient-derived organoid and patient-derived xenografts strategies for high-throughput drug screening.
[Clinical and Translational Gastroenterology] |
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| Researchers analyzed the association between the molecular characteristics which analyzed by next-generation sequencing and sensitivity to the extracellular signal-regulated kinase (ERK) inhibitor in patient-derived organoids derived from colorectal cancer specimens.
[Biochemical and Biophysical Research Communications] |
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| The authors comprehensively assessed the vasculature in two distinct kidney organoid models as well as in explanted embryonic kidneys.
[Developmental Biology] |
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| Scientists demonstrated that chemical manipulation of esophageal keratinocyte differentiation in mouse normal esophageal epithelial organoids implicated the involvement of the mouse homolog of ZNF750, Zfp750, in keratinocyte differentiation in premalignant cells.
[Oncology Letters] |
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| Investigators present the scientific evidence for how adult human tissues could generate human-animal interspecific chimeras to solve this problem.
[NPJ Regenerative Medicine] |
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| The 2021 Pershing Square Sohn Prize for Young Investigators in Cancer Research has been awarded to Christine Iok In Chio, PhD, and Xuebing Wu, PhD, for their out-of-the box approaches to cancer research.
[Columbia University] |
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| A University of Toronto (U of T) team is 11 sharing nearly $21 million in funding from Medicine by Design over three years. Funded by a $114-million grant from the Canada First Research Excellence Fund, Medicine by Design is a strategic research initiative that is working at the convergence of engineering, medicine and science to catalyze transformative discoveries in regenerative medicine and accelerate them toward clinical impact.
[University of Toronto] |
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| September 28 -30, 2021
Virtual |
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| | Louisiana State University – New Orleans, Louisiana, United States |
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| | Kings’s College London – London, England, United Kingdom |
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| | UMB School of Medicine – Baltimore, Maryland , United States |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | Elsevier – Cambridge, Massachusetts, United States |
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