Organoid News Volume 2.20 | May 27 2021

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    Justin.choi
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    2021-05-27 | ON 2.20


    Organoid News by STEMCELL Technologies
    Vol. 2.20 – 27 May, 2021
    TOP STORY

    Cardioids Reveal Self-Organizing Principles of Human Cardiogenesis

    Investigators established self-organizing cardioids from human PSCs that intrinsically specified, patterned, and morphed into chamber-like structures containing a cavity.
    [Cell]

    Full ArticlePress ReleaseGraphical Abstract

    Learn about standards for PSC banking by watching Dr. Glyn Stacey's webinar from the Nature Research Round Table on hPSC Quality
    PUBLICATIONSRanked by the impact factor of the journal

    Charting Human Development Using a Multi-Endodermal Organ Atlas and Organoid Models

    Scientists illuminated cell states, transcription factors, and organ-specific epithelial stem cell and mesenchyme interactions across lineages.
    [Cell]

    Full ArticleGraphical Abstract

    Co-Development of Central and Peripheral Neurons with Trunk Mesendoderm in Human Elongating Multi-Lineage Organized Gastruloids

    Researchers evaluated elongating multi-lineage organized over a 40 day period, applying immunofluorescence of multi-lineage and functional biomarkers, including day 16 single-cell RNA-Seq, and evaluation of ectodermal and non-ectodermal neural crest cells.
    [Nature Communications]

    Full Article

    Actuation Enhances Patterning in Human Neural Tube Organoids

    The authors showed that active mechanical forces increased growth and led to enhanced patterning in an organoid model of the neural tube derived from single human PSCs.
    [Nature Communications]

    Full Article

    LSD1 and Aberrant DNA Methylation Mediate Persistence of Enteroendocrine Progenitors That Support BRAF Mutant Colorectal Cancer

    The authors demonstrated that enteroendocrine progenitor cells were enriched in BRAF mutant colorectal cancer patient tumors, cell lines, and patient-derived organoids.
    [Cancer Research]

    Abstract

    High Yap and Mll1 Promote a Persistent Regenerative Cell State Induced by Notch Signaling and Loss of p53

    Using intestinal organoids, researchers showed that concomitant activation of Notch signaling and ablation of p53 induce a highly proliferative and regenerative cell state, which was associated with increased levels of Yap and the histone methyltransferase Mll1.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Direct Derivation of Human Alveolospheres for SARS-CoV-2 Infection Modeling and Drug Screening

    Investigators established an efficient human alveolosphere culture method and sphere-based drug testing platform for SARS-CoV-2.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Orphan Nuclear Receptor COUP-TFII Enhances Myofibroblast Glycolysis Leading to Kidney Fibrosis

    Scientists found increased COUP-TFII expression in myofibroblasts in human fibrotic kidneys, lungs, kidney organoids, and mouse kidneys after injury.
    [EMBO Reports]

    AbstractGraphical Abstract

    Anti-Tumor Effect of Trametinib in Bladder Cancer Organoid and the Underlying Mechanism

    In each bladder cancer organoid strain, epidermal growth factor receptor/ERK signaling was upregulated compared with normal bladder cells.
    [Cancer Biology & Therapy]

    Abstract

    In Vitro Co-Culture of Human Intestinal Organoids and Lamina Propria-Derived CD4+ T Cells

    Investigators provided a detailed protocol for an autologous in vitro long-term 3D co-culture system of human intestinal CD4+ T cells and intestinal stem cells to study T cell-intestinal epithelial cell interactions during tissue development and inflammation.
    [STAR Protocols]

    Full ArticleGraphical Abstract

    Click to learn more about the STEMdiff Cerebral Organoid Kit from STEMCELL Technologies
    REVIEWS

    Biomaterials for Intestinal Organoid Technology and Personalized Disease Modelling

    The authors discuss the status, applications, challenges and perspectives of intestinal organoid systems emphasising on hydrogels and their properties suitable for intestinal organoid culture.
    [Acta Biomaterialia]

    AbstractGraphical Abstract

    Unraveling Pathophysiology of Neurological and Psychiatric Complications of COVID-19 Using Brain Organoids

    With advancement of organoid technology, brain organoids offer a promising tool for unravelling pathophysiologic clues and potential therapeutic options for neuropsychiatric complications of COVID-19.
    [Neuroscientist]

    Full Article

    Patient-Derived Cancer Organoids for Precision Oncology Treatment

    Investigators explore the current literature on cancer organoids, highlighting the history of patient-derived organoids (PDOs) development, organoid models of glioma, and potential clinical applications of PDOs.
    [Journal of Personalized Medicine]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Limit on Lab-Grown Human Embryos Dropped by Stem-Cell Body

    The International Society for Stem Cell Research relaxed the famous 14-day rule on culturing human embryos in its latest research guidelines.
    [Nature News]

    Press Release

    Using 3D Brain Organoids to Study Prader-Willi Syndrome

    Dr. Partha Das of Monash University’s Biomedicine Discovery Institute has been announced as the recipient of the Prader Willi Research Foundation Australia 2020 Prader-Willi Syndrome (PWS) Grant Round. Dr. Das’ project will grow and study 3D brain organoids from people with PWS.
    [Monash University]

    Press Release
    FEATURED EVENT

    Organoids: Advances and Applications

    September 28 -30, 2021
    Virtual

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    JOB OPPORTUNITIES

    Research Associate – Senescence in Cancer

    University of Cambridge – Cambridge, England, United Kingdom

    Postdoctoral Researcher – Host-Microbiome Interactions

    Kings’s College London – London, England, United Kingdom

    Postdoctoral Fellow – Developmental and Reproductive Biology

    University of Maryland School of Medicine – Baltimore, Maryland, United States

    Research Fellow – Intestinal Stem Cells & Gastrointestinal Diseases

    Case Western Reserve University – Cleveland, Ohio, United States

    Senior Scientific Editor – Cell Stem Cell

    Elsevier – Cambridge, Massachusetts, United States

    > See All Jobs

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